Further evidence that the pigment in the Dubin-Johnson syndrome is not melanin.
Further evidence that the pigment in the Dubin-Johnson syndrome is not melanin.
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进一步的证据表明杜宾-约翰逊综合征中的色素不是黑色素。
DOI：
10.1111/j.1600-0749.1987.tb00392.x
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
J. Roth
中科院分区：
文献类型：
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作者：
H. Swartz;K. Chen;J. Roth
杜宾-约翰逊综合征 (DJS) 中的色素明确表明不是典型的黑色素或密切相关的聚合物。对肝癌 DJS 色素的电子自旋共振 (ESR) 研究表明，与真正的黑色素不同，与 DJS 综合征相关的色素在没有光的情况下不存在自由基。即使暴露在宽频率范围内的低水平可见光下，DJS 颜料也会产生自由基。之前的研究并未认识到这种色素对光的敏感性，因此错误地得出结论：DJS 色素具有永久性自由基。 DJS 组织中的光诱导 ESR 信号具有与任何已知黑色素显着不同的光谱特性。颜料不被亲脂性溶剂萃取，并在 50,000g 下离心，但不在 5,000g 下离心。
The pigment in the Dubin-Johnson syndrome (DJS) is shown unequivocally not to be a typical melanin or closely related polymer. In electron spin resonance (ESR) studies of DJS pigment from a hepatoma, it is shown that, unlike true melanins, the pigment associated with the DJS syndrome has no free radical in the absence of light. Exposure to even low levels of visible light over a broad frequency range induces a free radical in the DJS pigment. Previous studies did not appreciate the sensitivity to light of this pigment and therefore erroneously concluded that the DJS pigment had a permanent free radical. The light induced ESR signal in DJS tissue has spectroscopic properties that differ significantly from any known melanins. The pigment is not extracted by lipophilic solvents and is centrifuged down at 50,000g, but not at 5,000g.