Social facilitation of wound heating
Social facilitation of wound heating
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DOI：
10.1016/j.psyneuen.2003.10.003
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发表时间：
2004-09-01
影响因子：
3.7
通讯作者：
DeVries, AC
中科院分区：
文献类型：
--
作者：
Detillion, CE;Craft, TKS;DeVries, AC
有充分的证据表明，心理压力会损害人类和啮齿动物的伤口愈合。然而，大多数对伤口愈合影响的研究工作都集中在损害而不是促进加热的因素上。在本研究中，我们确定是否积极的社会互动，影响下丘脑-垂体-肾上腺（HPA）轴活动的社会啮齿动物，促进伤口加热。西伯利亚仓鼠接受皮肤伤口，然后暴露于制动应力。压力增加皮质醇，浓度和受损的伤口加热隔离，但不社会圈养，仓鼠。通过肾上腺切除术去除内源性皮质醇消除了应激对离体仓鼠伤口愈合的影响。用催产素（OT）治疗孤立的仓鼠，催产素是一种在社会接触过程中释放的激素，与社会联系有关，也阻止了应激诱导的皮质醇浓度增加，促进了伤口加热。相比之下，用OT拮抗剂治疗群居仓鼠延迟了伤口愈合。综上所述，这些数据表明，社会互动缓冲压力，并通过涉及OT诱导的HPA轴抑制的机制促进伤口加热。这些数据表明，社会隔离损害伤口加热，而OT治疗可能会改善社会隔离对健康的一些影响。(C)2003 Elsevier Ltd.保留所有权利。
It is well documented that psychological stress impairs wound healing in humans and rodents. However, most research effort into influences on wound healing has focused on factors that compromise, rather than promote, heating. In the present study, we determined if positive social interaction, which influences hypothalamic-pituitary-adrenal (HPA) axis activity in social rodents, promotes wound heating. Siberian hamsters received a cutaneous wound and then were exposed to immobilization stress. Stress increased cortisol, concentrations and impaired wound heating in isolated, but not socially housed, hamsters. Removal of endogenous cortisol via adrenalectomy eliminated the effects of stress on wound healing in isolated hamsters. Treatment of isolated hamsters with oxytocin (OT), a hormone released during social contact and associated with social bonding, also blocked stress-induced increases in cortisol concentrations and facilitated wound heating. In contrast, treating socially housed hamsters with an OT antagonist delayed wound healing. Taken together, these data suggest that social interactions buffer against stress and promote wound heating through a mechanism that involves OT-induced suppression of the HPA axis. The data imply that social isolation impairs wound heating, whereas OT treatment may ameliorate some effects of social isolation on health. (C) 2003 Elsevier Ltd. All rights reserved.