Changes of Hypocretin (Orexin) System in Schizophrenia: From Plasma to Brain
Changes of Hypocretin (Orexin) System in Schizophrenia: From Plasma to Brain
复制标题
精神分裂症中下丘脑分泌素（Orexin）系统的变化：从血浆到大脑
DOI：
10.1093/schbul/sbab042
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发表时间：
2021-05-11
影响因子：
6.6
通讯作者：
Bao, Ai-Min
中科院分区：
文献类型：
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作者：
Lu, Jing;Huang, Man-Li;Bao, Ai-Min
下丘脑泌素(也称为增食欲素)调节多种功能，如睡眠-觉醒节律、注意力、认知和能量平衡，这些功能在精神分裂症(SCZ)中显示出显著的变化。我们的目标是确定SCZ患者下丘脑肌酸系统的变化。我们检测了SCZ患者和健康对照组的血浆降克素-1水平，发现SCZ患者的血浆降克素-1水平显著降低，这主要是由于女性SCZ患者比女性对照组显著降低。此外，我们还检测了SCZ患者和对照组下丘脑下丘脑下丘脑下克汀病-1免疫反应性(Ir)、脑室脑脊液(CSF)下丘脑液中下丘脑下克汀醇-1水平和额上回(SFG)中下丘脑下克汀受体(Hcrt-R)mRNA的表达。此外，女性SCZ患者SFG中Hcrt-R2 mRNA的表达较女性对照组降低，而男性SCZ患者较男性对照组Hat-R1mRNA和Hcrt-R2 mRNA的表达有升高的趋势。我们得出结论，SCZ患者，尤其是女性患者，中枢下丘脑神经传递减少，这反映在血浆中。
Hypocretin (also called orexin) regulates various functions, such as sleep-wake rhythms, attention, cognition, and energy balance, which show significant changes in schizophrenia (SCZ). We aimed to identify alterations in the hypocretin system in SCZ patients. We measured plasma hypocretin-1 levels in SCZ patients and healthy controls and found significantly decreased plasma hypocretin-1 levels in SCZ patients, which was mainly due to a significant decrease in female SCZ patients compared with female controls. In addition, we measured postmortem hypothalamic hypocretin-1 -immunoreactivity (ir), ventricular cerebrospinal fluid (CSF) hypocretin-1 levels, and hypocretin receptor (Hcrt-R) mRNA expression in the superior frontal gyms (SFG) in SCZ patients and controls We observed a significant decrease in the amount of hypothalamic hypocretin-1 ir in SCZ patients, which was due to decreased amounts in female but not male patients. Moreover, Hcrt-R2 mRNA in the SFG was decreased in female SCZ patients compared with female controls, while male SCZ patients showed a trend of increased Hat-R1 mRNA and Hcrt-R2 mRNA expression compared with male controls. We conclude that central hypocretin neurotransmission is decreased in SCZ patients, especially female patients, and this is reflected in the plasma.