EVOLUTION OF THE MAJOR HISTOCOMPATIBILITY COMPLEX - MOLECULAR-CLONING OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I FROM THE AMPHIBIAN XENOPUS
EVOLUTION OF THE MAJOR HISTOCOMPATIBILITY COMPLEX - MOLECULAR-CLONING OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I FROM THE AMPHIBIAN XENOPUS
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DOI：
10.1073/pnas.88.2.537
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发表时间：
1991-01-01
影响因子：
11.1
通讯作者：
KASAHARA, M
中科院分区：
文献类型：
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作者：
FLAJNIK, MF;CANEL, C;KASAHARA, M
I类主要组织相容性复合体（MHC）cDNA克隆已从源自MHC纯合非洲爪蟾的mRNA的表达文库中分离。 核苷酸和预测的氨基酸序列显示出与高等脊椎动物的MHC I类分子的确定的相似性。 免疫球蛋白样α-3结构域更类似于哺乳动物II类β链的免疫球蛋白样结构域，而不是哺乳动物I类分子的免疫球蛋白样结构域，并提出了基于代表性MHC基因的核苷酸序列的树。
Class I major histocompatibility complex (MHC) cDNA clones have been isolated from an expression library derived from mRNA of an MHC homozygous Xenopus laevis. The nucleotide and predicted amino acid sequences show definite similarity to MHC class I molecules of higher vertebrates. The immunoglobulin-like alpha-3 domain is more similar to the immunoglobulin-like domains of mammalian class II beta chains than to those of mammalian class I molecules, and a tree based on nucleotide sequences of representative MHC genes is presented.