Cardiac pulsatility mapping and vessel type identification using laser speckle contrast imaging.
Cardiac pulsatility mapping and vessel type identification using laser speckle contrast imaging.
复制标题
DOI：
10.1364/boe.9.006388
复制
发表时间：
2018-11
影响因子：
3.4
通讯作者：
D. Postnov;Ş. E. Erdener;K. Kılıç;D. Boas
中科院分区：
文献类型：
--
作者：
D. Postnov;Ş. E. Erdener;K. Kılıç;D. Boas
由心动周期引起的全身血流变化在正常和病理条件下都可以发挥作用或成为一个重要的标志。血流脉冲的形状、大小和传播速度反映了血管系统的机械特性，并已知随着血管疾病的变化而显著变化。由于空间和/或时间分辨率的限制，大多数传统技术无法成像微循环中的心脏活动，而是通过在动脉沿线的两个点进行测量来推断传播速度。在这里，我们将激光散斑对比成像应用于小鼠大脑皮层心脏活动的高频谐波中具有高空间分辨率的图像。我们揭示心脏脉搏活动中与血管相关的变化，并使用这些信息自动识别动脉和静脉。
Systemic flow variations caused by the cardiac cycle can play a role or be an important marker in both normal and pathological conditions. The shape, magnitude and propagation speed of the flow pulse reflect mechanical properties of the vasculature and are known to vary significantly with vascular diseases. Most conventional techniques are not capable of imaging cardiac activity in the microcirculation due to spatial and/or temporal resolution limitations and instead make inferences about propagation speed by making measurements at two points along an artery. Here, we apply laser speckle contrast imaging to images with high spatial resolution in the high frequency harmonics of cardiac activity in the cerebral cortex of a mouse. We reveal vessel dependent variation in the cardiac pulse activity and use this information to automatically identify arteries and veins.