Effect of intravenous calcitonin gene-related peptide antagonist on the laryngeal chemoreflex in piglets.
Effect of intravenous calcitonin gene-related peptide antagonist on the laryngeal chemoreflex in piglets.
复制标题
静脉注射降钙素基因相关肽拮抗剂对仔猪喉化学反射的影响。
DOI：
10.1016/s0194-5998(99)70113-0
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Luschei,ES
中科院分区：
文献类型：
--
作者：
Bauman,NM;Wang,D;Jaffe,DA;Sandler,AD;Luschei,ES
1999年7月mation是已知的关于神经递质和神经调质的反射。降钙素基因相关肽（α CGRP）是一种由37个氨基酸组成的肽，被认为主要由感觉神经元释放。9 α CGRP在动物之间显示出最小的变异性10，并且可以在哺乳动物中枢和外周神经系统以及哺乳动物喉的粘膜和粘膜下层中通过化学方法检测到。11 - 13普遍存在的肽具有许多作用，并且可以作为神经递质、神经调质、局部激素，甚至作为神经营养因子发挥作用。[9]由于这种肽经常与已建立的神经递质共存，因此被认为主要起神经调质的作用。14本研究通过比较全身给予α CGRP 8 - 37（一种α CGRP竞争性拮抗剂）前后仔猪的反射反应，研究了α CGRP在LCR中的作用。
July 1999 mation is known regarding the neurotransmitters and neuromodulators of the reflex. Calcitonin gene-related peptide (αCGRP) is a 37 amino acid peptide that is thought to be released primarily from sensory neurons. 9 αCGRP shows minimal variability between animals10 and may be detected immunohistochemically in both the central and peripheral mammalian nervous systems as well as in the mucosa and submucosa of the mammalian larynx. 11-13 The ubiquitous peptide serves a number of roles and may function as a neurotransmitter, a neuromodulator, a local hormone, and even as a neurotrophic factor. 9 Because the peptide is so often found colocalized with established neurotransmitters, it is thought to function primarily as a neuromodulator. 14 This study investigates the role of αCGRP in the LCR by comparing the reflex response in piglets before and after systemic administration of αCGRP 8-37, a competitive antagonist of αCGRP.