The Effects of Aspirin in Gestation and Reproduction (EAGeR) Trial: A Story of Discovery.
The Effects of Aspirin in Gestation and Reproduction (EAGeR) Trial: A Story of Discovery.
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阿司匹林对妊娠和生殖 (EAGeR) 试验的影响：一个发现的故事。
DOI：
10.1055/s-0037-1606384
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发表时间：
2017
影响因子：
2.7
通讯作者：
Schisterman,EnriqueF
中科院分区：
文献类型：
--
作者：
Connell,MatthewT;Sjaarda,LindseyA;Radin,RoseG;Kuhr,Daniel;Mumford,SunniL;Plowden,TorieC;Silver,RobertM;Schisterman,EnriqueF
人类的繁殖是一个效率低下的过程。有几个驱动因素的并发症沿着的路径和怀孕期间，其中之一是炎症。用廉价且广泛可用的药物（如阿司匹林）来减轻异常炎症的有害影响，可能会产生巨大的全球影响。阿司匹林对妊娠和生殖的影响（EAGeR）试验招募了年龄在18至40岁之间的女性，既往有1至2次妊娠失败，未诊断为不孕症。患者随机接受低剂量阿司匹林或安慰剂治疗。在这里，我们回顾了迄今为止EAGeR试验的集体发现，并讨论了从这项开创性试验的独特数据中吸取的几个重要教训。这项试验报告的结果为理解阿司匹林在调节生殖过程中的潜在机制以及炎症在这些过程中的作用提供了重大进展。本文综述了EAGeR试验的集体发现，在现有文献的背景下，关于阿司匹林和炎症的生殖，以告知相关的生育和产科研究的下一步，以及对临床护理的潜在影响。
Human reproduction is an inefficient process. There are several drivers of complications along the path to and during pregnancy, one of which is inflammation. Treatments to mitigate the deleterious effects of aberrant inflammation with something inexpensive and widely available like aspirin could have dramatic global impact. The Effects of Aspirin in Gestation and Reproduction (EAGeR) trial enrolled women aged 18 to 40 years with one to two prior pregnancy losses and no diagnosis of infertility. Patients were randomized to either low-dose aspirin or placebo. Here, we review the collective findings of the EAGeR trial to date and discuss several important lessons learned from the unique data resulting from this groundbreaking trial. Findings reported from this trial provide significant advances in the understanding of aspirin's potential mechanisms in modulating reproductive processes and the role of inflammation in these processes. This review describes the collective findings of the EAGeR trial in the context of the existing literature regarding aspirin and inflammation in reproduction to inform relevant next steps in fertility and obstetric research, as well as potential implications for clinical care.