Competence for transformation: a matter of taste.
Competence for transformation: a matter of taste.
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转型能力：品味问题。
DOI：
10.1016/s1369-5274(99)00026-0
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Dubnau,D
中科院分区：
文献类型：
--
作者：
Tortosa,P;Dubnau,D
枯草芽孢杆菌和肺炎链球菌的遗传能力以及金黄色葡萄球菌的毒力都受到群体感应机制的调节，该机制使用双组分信号转导系统来响应胞外肽信息素。最近的数据表明，在所有三个系统密切相关的菌株表达显着不同的信息素和多位膜受体蛋白。这种多态性可能作为一种性隔离机制。在B。在枯草芽孢杆菌中，感受态调节途径的下游区段通过控制关键转录因子的稳定性而起作用。In S.在肺炎链球菌中，下游区段涉及次要σ因子的转录激活，所述次要σ因子又负责晚期感受态基因的表达。
Genetic competence in both Bacillus subtilis and Streptococcus pneumoniae, as well as virulence in Staphylococcus aureus, are regulated by quorum-sensing mechanisms that use two-component signal transduction systems to respond to extracellular peptide pheromones. Recent data indicate that in all three systems closely related strains express markedly different pheromones and polytopic membrane receptor proteins. This polymorphism may function as a sexual isolation mechanims. In B. subtilis the downstream segment of the competence regulatory pathway acts by controlling the stability of a key transcription factor. In S. pneumoniae the downstream segment involves the transcriptional activation of a minor sigma factor that is in turn responsible for the expression of late competence genes.