Vascular extracellular signal-regulated kinase mediates migraine-related sensitization of meningeal nociceptors.
Vascular extracellular signal-regulated kinase mediates migraine-related sensitization of meningeal nociceptors.
复制标题
DOI：
10.1002/ana.23873
复制
发表时间：
2013-06
影响因子：
11.2
通讯作者：
Levy, Dan
中科院分区：
文献类型：
--
作者：
Zhang, XiChun;Kainz, Vanessa;Zhao, Jun;Strassman, Andrew M.;Levy, Dan
To examine changes in the response properties of meningeal nociceptors that might lead to migraine pain and examine endogenous processes that could play a role in mediating them using a clinically relevant model of migraine triggering, namely infusion of the NO donor nitroglycerin (NTG). Single unit recordings made in the trigeminal ganglion of rats were used to test changes in the activity and mechanosensitivity of meningeal nociceptors in response to administration of the migraine trigger NTG or another NO donor SNAP at doses relevant to the human model of migraine headache. Immunohistochemistry and pharmacological manipulations were used to investigate the possible role of meningeal vascular signaling in mediating the responses of meningeal nociceptors to NO. Infusion of NTG promoted a delayed and robust increase in the mechanosensitivity of meningeal nociceptors with a time course resembling the development of the delayed migraine headache. A similar sensitization was elicited by dural application of NTG and SNAP. NTG-evoked delayed meningeal nociceptor sensitization was associated with a robust ERK phosphorylation in meningeal arteries. Pharmacological blockade of meningeal ERK phosphorylation inhibited the development of NTG-evoked delayed meningeal nociceptor sensitization The development of delayed mechanical sensitization evoked by the migraine trigger NTG is potentially of great importance as the first finding of a neurophysiological correlate of migraine headache in meningeal nociceptors. The arterial ERK phosphorylation and its involvement in mediating the NTG-evoked delayed sensitization points to an important, yet unappreciated, role of the meningeal vasculature in the genesis of migraine pain.
登录
查看更多内容
DOI：
10.1111/j.1468-2982.2009.01873.x
发表时间：
2009-12
期刊：
Cephalalgia : an international journal of headache
影响因子：
--
作者：
De Felice M;Porreca F
通讯作者：
Porreca F
影响因子：
4.9
作者：
Charles, Andrew
通讯作者：
Charles, Andrew
影响因子：
4.8
作者：
Komalavilas, P;Shah, PK;Lincoln, TM
通讯作者：
Lincoln, TM
影响因子：
2.5
作者：
Koulchitsky, S;Fischer, MJM;Messlinger, K
通讯作者：
Messlinger, K
影响因子：
5.5
作者：
Levy, D;Strassman, AM
通讯作者：
Strassman, AM