Hepatocellular carcinoma epidemiology
Hepatocellular carcinoma epidemiology
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DOI：
10.1016/j.bpg.2014.08.007
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发表时间：
2014-10-01
影响因子：
3.2
通讯作者：
La Vecchia, Carlo
中科院分区：
文献类型：
--
作者：
Bosetti, Cristina;Turati, Federica;La Vecchia, Carlo
原发性肝癌(即肝细胞癌)是世界范围内男性第五大常见癌症，女性第七大常见癌症，是导致癌症死亡的第三大原因。东亚/东南亚和非洲的肝癌发病率特别高，南欧处于中等水平，大多数高收入国家的肝癌发病率较低。乙肝病毒或丙型肝炎病毒持续感染是公认的肝细胞癌的主要危险因素。黄曲霉毒素暴露也是非洲和东亚发生肝癌的一个重要风险因素。在高收入国家，大量饮酒、吸烟、超重、糖尿病、家庭/遗传因素以及选定的饮食因素都有相关作用。本综述提供了欧洲、美国、日本和澳大利亚最新的肝细胞癌死亡率的地理分布和时间趋势，并概述了相关的肝细胞癌病因和预防这种肿瘤的主要措施。(C)2014爱思唯尔有限公司。保留所有权利。
Primary liver cancer (namely hepatocellular carcinoma, HCC) is worldwide the fifth most common cancer in men and the seventh one in women, and it represents the third most frequent cause of cancer death. HCC rates are particularly high in eastern/southeastern Asia and in Africa, intermediate in Southern Europe, and low in most high-income countries. Persistent infections by HBV or HCV are the main recognized risk factors for HCC. Aflatoxin exposure is also an important risk factor for HCC development in Africa and eastern Asia. In high-income countries heavy alcohol drinking, tobacco smoking, overweight, diabetes, familial/genetic factors, and selected dietary aspects, have a relevant role. Updated geographic patterns and time trends in mortality from HCC in Europe, USA, Japan, and Australia are provided in the present review, together with an overview of relevant etiologic factors for HCC and main measures for the prevention of this neoplasm. (C) 2014 Elsevier Ltd. All rights reserved.