Multi-exposure interferometric diffusing wave spectroscopy.
Multi-exposure interferometric diffusing wave spectroscopy.
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DOI：
10.1364/ol.427746
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发表时间：
2021-09-15
期刊：
影响因子：
3.6
通讯作者：
Srinivasan, Vivek J.
中科院分区：
文献类型：
--
作者：
Zhou, Wenjun;Zhao, Mingjun;Kholiqov, Oybek;Srinivasan, Vivek J.
我们提出了多暴露干涉漫射波光谱（MiDWS），它可以连续和无创地测量脑血流指数（BFI）。MiDWS采用干涉测量法检测弱光水平，通过改变传感器曝光时间间接探测光场自相关。本文将MiDWS与传统的干涉漫射波光谱和散斑对比光谱在幻影中的应用进行了比较。值得注意的是，MiDWS方法可以在短曝光时间内使用低帧率的二维互补金属氧化物半导体相机，其中探测器噪声大大超过样品光子计数。最后，我们发现MiDWS可以在单个摄像机上同时在成人头部的两个源收集器分离处（1 cm和3 cm）监测BFI，从而可以使用表面信号回归技术来提高大脑特异性。
We present multi-exposure interferometric diffusing wave spectroscopy (MiDWS), which measures brain blood flow index (BFI) continuously and non-invasively. MiDWS employs interferometry to detect low light levels, probing the optical field autocorrelation indirectly by varying the sensor exposure time. Here MiDWS is compared with conventional interferometric diffusing wave spectroscopy and speckle contrast optical spectroscopy in phantoms. Notably, the MiDWS approach enables the use of low frame rate, two-dimensional complementary metal–oxide semiconductor cameras in a short exposure time regime, where detector noise greatly exceeds the sample photon count. Finally, we show that MiDWS can monitor the BFI simultaneously at two source-collector separations (1 and 3 cm) on the adult human head on a single camera, enabling the use of superficial signal regression techniques to improve brain specificity.