Gap prepulse inhibition of the auditory late response in healthy subjects
Gap prepulse inhibition of the auditory late response in healthy subjects
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DOI：
10.1111/psyp.12507
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发表时间：
2015-11-01
期刊：
影响因子：
3.7
通讯作者：
Kim, Hee Chan
中科院分区：
文献类型：
--
作者：
Ku, Yunseo;Ahn, Joong Woo;Kim, Hee Chan
在动物研究中，间隙惊吓范式已被用作耳鸣筛查的行为方法。本研究旨在探讨人类听觉晚反应（ALR）作为间隔强声范式的客观反应的间隔前脉冲抑制（GPI）。在27名健康受试者中记录了对间隙强度和无间隙强度声音刺激的ALR。比较两个平均ALR之间的基线-峰值（N1、P2和N2）和峰-峰值（N1 P2和P2 N2）振幅。通过增加刺激重复次数，分析实验过程中N1 P2和P2 N2抑制率的变化。刺激参数调整对GPI比率的影响进行了评估。无间隙的强烈的声音刺激引起更大的峰值振幅比间隙的强烈的声音刺激，并发现在所有的峰值显着差异。总体平均抑制比显著低于1.0，其中值1.0表明间隙强度和无间隙强度声音反应之间没有差异。GPI比率的初始下降显示在N1 P2和P2 N2复合物中，并且在100次刺激重复后这种降低几乎完全。观察到间隙长度和刺激间隔对GPI比率的显著影响。我们发现在健康受试者中，ALR峰值幅度在执行间隙-强烈声音范例中受到显著抑制。N1 P2复合体在抑制程度和重测信度方面较好地代表了GPI。我们的研究结果提供了实用的信息，健康人和耳鸣患者的比较研究，使用间隙强声音范式与ALR。
The gap-startle paradigm has been used as a behavioral method for tinnitus screening in animal studies. This study aimed to investigate gap prepulse inhibition (GPI) of the auditory late response (ALR) as the objective response of the gap-intense sound paradigm in humans. ALRs were recorded in response to gap-intense and no-gap-intense sound stimuli in 27 healthy subjects. The amplitudes of the baseline-to-peak (N1, P2, and N2) and the peak-to-peak (N1P2 and P2N2) were compared between two averaged ALRs. The variations in the inhibition ratios of N1P2 and P2N2 during the experiment were analyzed by increasing stimuli repetitions. The effect of stimulus parameter adjustments on GPI ratios was evaluated. No-gap-intense sound stimuli elicited greater peak amplitudes than gap-intense sound stimuli, and significant differences were found across all peaks. The overall mean inhibition ratios were significantly lower than 1.0, where the value 1.0 indicates that there were no differences between gap-intense and no-gap-intense sound responses. The initial decline in GPI ratios was shown in N1P2 and P2N2 complexes, and this reduction was nearly complete after 100 stimulus repetitions. Significant effects of gap length and interstimulus interval on GPI ratios were observed. We found significant inhibition of ALR peak amplitudes in performing the gap-intense sound paradigm in healthy subjects. The N1P2 complex represented GPI well in terms of suppression degree and test-retest reliability. Our findings offer practical information for the comparative study of healthy subjects and tinnitus patients using the gap-intense sound paradigm with the ALR.