Dissociation between time reproduction of actions and of intervals in patients with Parkinson’s disease
Dissociation between time reproduction of actions and of intervals in patients with Parkinson’s disease
复制标题
帕金森病患者的动作时间再现与间隔时间之间的分离
作者：
D. Torta;L. Castelli;Luca Latini;Alessandra Banche;L. Lopiano;G. Geminiani
在帕金森病（PD）患者中观察到时间估计的改变，并与多巴胺能功能障碍有关。然而，左旋多巴治疗和丘脑底核（DBS-丘脑底核）的脑深部刺激已被证明可以改善此类患者的运动缺陷和时间估计技能。到目前为止，PD患者的时间估计任务已经评估了再现时间间隔的能力，但从未评估过动作的持续时间。在这里，我们调查：（1）PD患者再现其先前动作的持续时间的能力与再现时间间隔的能力相比，以及（2）DBS-刺激对这两种技能的影响。19例帕金森病患者与DBS-19对照组被要求重现的持续时间的行动和时间的间隔。在以下治疗条件下对患者进行测试：开启刺激/关闭药物、关闭刺激/关闭药物和关闭刺激/开启药物。结果表明，在关闭刺激/关闭药物治疗条件下，患者在准确再现时间间隔持续时间的同时，其动作持续时间再现不足。在两种治疗方案中，性能的准确性显著提高。我们的研究结果表明，在PD患者再现运动行为的能力可以从再现的时间间隔分离，它可以通过药物或手术治疗的管理得到改善。
Alterations in temporal estimation have been observed in patients with Parkinson’s disease (PD) and have been associated to dopaminergic dysfunction. Nevertheless, levodopa treatment and deep brain stimulation of the subthalamic nucleus (DBS-STN) have been shown to improve motor deficits and temporal estimation skills in such patients. So far, temporal estimation tasks in PD patients have evaluated the ability to reproduce intervals of time, but never the duration of an action. Here we investigated: (1) the ability of PD patients to reproduce the duration of their previous actions as compared to their ability to reproduce intervals of time and (2) the effect that DBS-STN has on both skills. Nineteen PD patients with DBS-STN and 19 controls were requested to reproduce the duration of an action and that of an interval of time. The patients were tested in the following treatment conditions: on stimulation/off medication, off stimulation/off medication and off stimulation/on medication. The results demonstrated that patients in the off stimulation/off medication condition under-reproduced the duration of their actions while accurately reproducing the duration of time intervals. The accuracy of the performance improved significantly in both treatment regimens. Our results indicate that in PD patients the ability to reproduce motor acts can be dissociated from that of reproducing time intervals and that it can be improved by the administration of medical or surgical treatment.
影响因子：
14.5
作者：
Alberts, Jay L.;Voelcker-Rehage, Claudia;Vitek, Jerrold L.
通讯作者：
Vitek, Jerrold L.