From molecules to mastication: the development and evolution of teeth.
From molecules to mastication: the development and evolution of teeth.
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DOI：
10.1002/wdev.63
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发表时间：
2013-03
影响因子：
--
通讯作者：
Klein, Ophir D.
中科院分区：
文献类型：
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作者：
Jheon, Andrew H.;Seidel, Kerstin;Biehs, Brian;Klein, Ophir D.
牙齿是脊椎动物所特有的，在它们的进化中起着核心作用。在过去的几十年里，牙齿发育的分子途径和形态发生过程一直是研究的焦点，牙齿是许多研究领域的重要模型系统。发育生物学家已经利用牙齿发育过程中上皮和底层间充质之间的明显区别来阐明器官发生过程中上皮/间充质的相互作用。牙齿在化石记录中的保存使得这些小器官对于古生物学家，人类学家和进化生物学家的工作至关重要。此外，随着最近对牙齿干细胞的鉴定和表征，牙齿已成为再生医学领域的兴趣。本文综述了牙齿发育和进化的主要研究领域，包括牙齿发育的形态发生、遗传学和信号传导、牙齿发育的进化和牙齿干细胞。还包括microRNA和人类疾病的简要讨论，因为它们适用于牙齿。
Teeth are unique to vertebrates and have played a central role in their evolution. The molecular pathways and morphogenetic processes involved in tooth development have been the focus of intense investigation over the past few decades, and the tooth is an important model system for many areas of research. Developmental biologists have exploited the clear distinction between the epithelium and the underlying mesenchyme during tooth development to elucidate reciprocal epithelial/mesenchymal interactions during organogenesis. The preservation of teeth in the fossil record makes these small organs essential for the work of paleontologists, anthropologists, and evolutionary biologists. In addition, with the recent identification and characterization of dental stem cells, teeth have become of interest to the field of regenerative medicine. Here, we review the major research areas and studies in the development and evolution of teeth, including morphogenesis, genetics and signaling, evolution of tooth development, and dental stem cells. Brief discussions of microRNAs and human disease as they apply to teeth are also included.