Beyond Transcription: Fine-Tuning of Circadian Timekeeping by Post-Transcriptional Regulation
Beyond Transcription: Fine-Tuning of Circadian Timekeeping by Post-Transcriptional Regulation
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DOI：
10.3390/genes9120616
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发表时间：
2018-12
期刊：
影响因子：
3.5
通讯作者：
J. Mateos;María José de Leone;Jeanette C. Torchio;M. Reichel;D. Staiger
中科院分区：
文献类型：
--
作者：
J. Mateos;María José de Leone;Jeanette C. Torchio;M. Reichel;D. Staiger
生物钟是重要的内源性计时器，帮助植物为环境中光明和黑暗的周期性变化做好准备。这种分子计时器的发条装置由时钟蛋白组成，它们以 24 小时的节律调节自身基因的转录。此外，有节奏地表达的时钟蛋白调节下游基因的时间依赖性转录，导致大部分转录组的信使 RNA (mRNA) 振荡。除了时钟的转录调控之外，mRNA 中的昼夜节律在很大程度上依赖于转录后调控，包括选择性前 mRNA 剪接、mRNA 降解和翻译控制。在这里，我们提出了拟南芥转录后调控对核心时钟功能和昼夜节律基因表达调控的贡献的最新见解。
The circadian clock is an important endogenous timekeeper, helping plants to prepare for the periodic changes of light and darkness in their environment. The clockwork of this molecular timer is made up of clock proteins that regulate transcription of their own genes with a 24 h rhythm. Furthermore, the rhythmically expressed clock proteins regulate time-of-day dependent transcription of downstream genes, causing messenger RNA (mRNA) oscillations of a large part of the transcriptome. On top of the transcriptional regulation by the clock, circadian rhythms in mRNAs rely in large parts on post-transcriptional regulation, including alternative pre-mRNA splicing, mRNA degradation, and translational control. Here, we present recent insights into the contribution of post-transcriptional regulation to core clock function and to regulation of circadian gene expression in Arabidopsis thaliana.