Pantomime of tool use depends on integrity of left inferior frontal cortex
Pantomime of tool use depends on integrity of left inferior frontal cortex
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DOI：
10.1093/cercor/bhm004
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发表时间：
2007-12-01
期刊：
影响因子：
3.7
通讯作者：
Karnath, Hans-Otto
中科院分区：
文献类型：
--
作者：
Goldenberg, Georg;Hermsdoerfer, Joachim;Karnath, Hans-Otto
使用工具的哑剧是一种常用的失用症测试。对于基本的认知神经科学来说，工具使用的哑剧很有趣，因为它构成了工具性和交流性手动动作之间的联系。我们使用病灶减影分析来确定与左脑损伤和失语症患者工具使用缺陷哑剧相关的特定部位。从有缺陷的哑剧中减去正常哑剧患者的病变，在额下回和邻近的额前回和中央前回的部分产生了最大的差异。当通过选择与这些措施等同的患者来控制语言理解受损和病变大小的可能混杂影响时，以及当仅考虑保留模仿手势的患者时，这一结果基本相同。相比之下，顶叶病变没有特定的影响哑剧。我们推测，哑剧的脆弱性，左下额叶皮层的病变是由于高要求的选择一个非常有限的范围内的功能的许多功能，可能会想到当想象实际使用的工具。
Pantomime of tool use is a frequently used test for apraxia. For basic cognitive neuroscience, pantomime of tool use is of interest because it constitutes a link between instrumental and communicative manual actions. We used lesion subtraction analysis to determine the locations specifically associated with defective pantomime of tool use in patients with left-brain damage and aphasia. Subtraction of lesions of patients with normal pantomime from those with defective pantomime yielded a maximum difference in the inferior frontal gyrus and adjacent portions of the insula and precentral gyrus. This result remained essentially the same when possible confounding influences of impaired language comprehension and of lesion size were controlled by selecting patients equated on these measures and when only patients with preserved imitation of gestures were considered. By contrast, parietal lesions did not have a specific impact on pantomime. We speculate that the vulnerability of pantomime to lesions of left inferior frontal cortex is due to the high demands on selection of a very restrained range of features out of the many features that may come to mind when imagining the actual use of the tool.