Decreased TIM-3 expression of peripheral blood natural killer cells in patients with severe aplastic anemia
Decreased TIM-3 expression of peripheral blood natural killer cells in patients with severe aplastic anemia
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重症再生障碍性贫血患者外周血自然杀伤细胞TIM-3表达降低
DOI：
10.1016/j.cellimm.2017.03.003
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发表时间：
2017-08-01
影响因子：
4.3
通讯作者：
Fu, Rong
中科院分区：
文献类型：
--
作者：
Zhang, Tian;Yuan, Xin;Fu, Rong
重型再生障碍性贫血（SAA）是一种以严重的全血细胞减少和骨髓衰竭为特征的自身免疫性疾病。我们在以往的研究中发现SAA患者存在NK细胞异常。T细胞免疫球蛋白粘蛋白-3（TIM-3）是一种重要的免疫调节因子，广泛存在于NK细胞上，可作为NK细胞活化和成熟的标志物。在本研究中，我们发现SAA未经治疗的患者与正常对照相比，NK细胞和CD 56 dim NK亚群上的TIM-3表达降低，并且与SAA全血细胞减少的严重程度相关。免疫抑制治疗后，TIM-3表达恢复至正常水平。IST后SAA缓解患者NK细胞中TIM-3 mRNA水平显著升高。提示NK细胞上TIM-3的低表达可能导致NK细胞功能障碍，并参与SAA骨髓衰竭的发生。
Severe aplastic anemia (SAA) is an autoimmune disease characterized by severe pancytopenia and bone marrow failure. In our previous studies, we found natural killer (NK) cells were aberrant in SAA patients. T cell immunoglobulin mucin-3 (TIM-3), an important regulator of immunity, is widely detected on NK cells and may contribute as a marker of activation and maturation of NK cells. In this study, we found that SAA untreated patients had lower TIM-3 expression on NK cells and CD56dim NK subsets compared with normal controls, and were correlated with the severity of pancytopenia of SAA. After immunosuppressive therapy (IST), TIM-3 expression recovered to normal level. Moreover, the TIM-3 mRNA levels in NK cells significantly increased in SAA remission patients after IST. We inferred that low expression of TIM-3 on NK cells might lead to NK cells dysfunction and involve in the progress of bone marrow failure in SAA.