SOURCE OF PLASMA PRORENIN IN EARLY AND LATE PREGNANCY - OBSERVATIONS IN A PATIENT WITH PRIMARY OVARIAN FAILURE
SOURCE OF PLASMA PRORENIN IN EARLY AND LATE PREGNANCY - OBSERVATIONS IN A PATIENT WITH PRIMARY OVARIAN FAILURE
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DOI：
10.1210/jcem-65-2-349
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发表时间：
1987-08-01
影响因子：
5.8
通讯作者：
SCHALEKAMP, MADH
中科院分区：
文献类型：
--
作者：
DERKX, FHM;ALBERDA, AT;SCHALEKAMP, MADH
在患有原发性卵巢功能衰竭的女性中测量了酶活性肾素（活性肾素）和无活性肾素（肾素原）的血浆水平，该女性通过诱导人工周期和用其丈夫的精子受精的捐赠卵母细胞进行体外受精来建立妊娠。结果与九名正常孕妇的结果进行了比较。患者孕前血浆活性肾素和肾素原水平正常。患者和正常孕妇在怀孕期间的活性肾素均升高了 2 倍。在怀孕的前 8 周，患者体内肾素原上升了 156 .mu.U/mL，而此时则上升了 869 .+-。正常孕妇为 169 .mu.U/mL（平均值 .+-.SD）。因此，该患者体内肾素原的升高远低于正常水平。肾素原在整个怀孕期间一直保持异常低水平，持续了 40 周。因此，怀孕期间正常出现的高肾素原水平可能取决于正常的卵巢功能。患者羊水肾素原与正常孕妇相似，比血浆高75倍。这一发现表明，患者绒毛膜细胞产生的肾素原是正常的，并且绒毛膜肾素原对母体血浆中肾素原的水平没有任何重大影响。由于这些发现，并根据最近的证据表明，在周期过度刺激的女性中，卵巢分泌肾素原并产生高血浆肾素原水平，我们得出结论，卵巢是孕妇血浆肾素原水平升高的主要来源。
The plasma levels of enzymatically active renin (active renin) and inactive renin (prorenin) were measured in a woman with primary ovarian failure, in who pregnancy was established by the induction of an artificial cycle and in vitro fertilization of a donated oocyte fertilized with the sperm of her husband. The results were compared with those in nine normal pregnant women. Prepregnancy plasma active renin and prorenin levels were normal in the patient. Active renin rose 2-fold during pregnancy in both the patient and the normal pregnant women. In the first 8 weeks of pregnancy prorenin rose by 156 .mu.U/mL in the patient, whereas it rose by 869 .+-. 169 .mu.U/mL (mean .+-. SD) in the normal pregnant women. Thus, the rise in prorenin in our patient was much less than normal. Prorenin remained abnormally low throughout the pregnancy, which lasted 40 weeks. Therefore, the high prorenin levels that occur normally during pregnancy may depend on normal ovarian function. Amniotic fluid prorenin in the patient was similar to that in normal pregnant women and was 75 times higher than that in plasma. This finding suggests that prorenin production by the chorionic cells was normal in the patient and that chorionic prorenin does not contribute in any major degree to the level of prorenin in maternal plasma. Because of these findings and in light of recent evidence that the ovary secretes prorenin and produces high plasma prorenin levels in women with hyperstimulated cycles, we conclude that the ovary is the main source of the elevated plasma prorenin levels in pregnant women.