Alterations in central and peripheral adrenergic receptors in deoxycorticosterone/salt hypertensive rats.
Alterations in central and peripheral adrenergic receptors in deoxycorticosterone/salt hypertensive rats.
复制标题
脱氧皮质酮/盐高血压大鼠中枢和外周肾上腺素能受体的变化。
DOI：
10.1016/0024-3205(80)90512-3
复制
发表时间：
1980
期刊：
影响因子：
6.1
通讯作者：
Roeske,WR
中科院分区：
文献类型：
--
作者：
Yamada,S;Yamamura,HI;Roeske,WR
未去肾大鼠给予脱氧皮质酮（DOCA）和盐治疗6周，可引起明显的收缩期高血压和心、肾肥厚。与未切除肾盐负荷对照大鼠相比，DOCA/盐高血压大鼠心脏α1-、β-和肾脏α1-肾上腺素受体密度显著降低。相反，高血压大鼠的大脑皮层、纹状体、海马和下丘脑/丘脑的肾上腺素能受体结合明显增加。而高血压大鼠大部分组织中毒蕈碱胆碱能受体和[3H]育亨宾结合位点未见改变。本研究提示中枢和外周α1-和β-肾上腺素受体在高血压发病中起重要作用。
The treatment of uninephrectomized rats with deoxycorticosterone (DOCA) and salt for 6 weeks caused a significant systolic hypertension and cardiac and renal hypertrophy. There was a significant decrease in the density of cardiac α1- and β-, and renal α1-adrenoceptors in DOCA/salt hypertensive rats, as compared to uninephrectomized salt loaded control rats. In contrast, the cerebral cortex, corpus striatum, hippocampus and hypothalamus/thalamus of hypertensive rats showed a significant increase in adrenoceptor binding in these hypertensive rats. In contrast, muscarinic cholinergic receptors and [3H]yohimbine binding sites were not altered in most tissues of the hypertensive rats. The present study suggests an important role for central and peripheral α1- and β-adrenoceptors in the pathogenesis of hypertension.