Temporal Learning Among Prefrontal and Striatal Ensembles.
Temporal Learning Among Prefrontal and Striatal Ensembles.
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DOI：
10.1093/texcom/tgaa058
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发表时间：
2020
影响因子：
--
通讯作者：
Narayanan NS
中科院分区：
文献类型：
--
作者：
Emmons E;Tunes-Chiuffa G;Choi J;Bruce RA;Weber MA;Kim Y;Narayanan NS
行为灵活性需要前额叶皮层和纹状体，但目前还不清楚这些结构在适应新环境方面是否发挥了相似或不同的作用。在这里，我们调查的内侧额叶皮层（MFC）和背内侧纹状体（DMS）在一种形式的行为灵活性：学习一个新的时间间隔的神经元合奏。我们研究了皮质纹状体神经元活动的啮齿类动物训练后，12秒的固定间隔（FI 12）学会在较短的3秒固定间隔（FI 3）的反应。在FI 12试验中，我们发现一种关键形式的时间处理--与时间相关的斜坡活动--在MFC中减少，但在DMS中没有变化，因为动物学会了以更短的间隔做出反应。然而，虽然MFC和DMS斜坡是稳定的，连续几天的两个间隔的性能，时间解码DMS合奏改善FI 3试验。最后，当比较FI 12与FI 3试验时，我们发现更多的DMS神经元比MFC神经元在两个间隔的表现中表现出差异的间隔相关活动。这些数据表明，MFC和DMS在时间学习过程中发挥不同的作用，并提供深入了解皮质纹状体电路。
Behavioral flexibility requires the prefrontal cortex and striatum, but it is unclear if these structures play similar or distinct roles in adapting to novel circumstances. Here, we investigate neuronal ensembles in the medial frontal cortex (MFC) and the dorsomedial striatum (DMS) during one form of behavioral flexibility: learning a new temporal interval. We studied corticostriatal neuronal activity as rodents trained to respond after a 12-s fixed interval (FI12) learned to respond at a shorter 3-s fixed interval (FI3). On FI12 trials, we found that a key form of temporal processing—time-related ramping activity—decreased in the MFC but did not change in the DMS as animals learned to respond at a shorter interval. However, while MFC and DMS ramping was stable with successive days of two-interval performance, temporal decoding by DMS ensembles improved on FI3 trials. Finally, when comparing FI12 versus FI3 trials, we found that more DMS neurons than MFC neurons exhibited differential interval-related activity early in two-interval performance. These data suggest that the MFC and DMS play distinct roles during temporal learning and provide insight into corticostriatal circuits.