Macrophage Migration Inhibitory Factor Contributes Angiogenesis by Up-Regulating IL-8 and Correlates With Poor Prognosis of Patients With Primary Nasopharyngeal Carcinoma
Macrophage Migration Inhibitory Factor Contributes Angiogenesis by Up-Regulating IL-8 and Correlates With Poor Prognosis of Patients With Primary Nasopharyngeal Carcinoma
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DOI：
10.1002/jso.21728
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发表时间：
2010-12-01
影响因子：
2.5
通讯作者：
Li, Bin
中科院分区：
文献类型：
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作者：
Liao, Bing;Zhong, Bi-Ling;Li, Bin
背景和目标：为探讨巨噬细胞移动抑制因子（macrophagemigrationinhibitoryfactor，MIF）与鼻咽癌（nasopharyngealcarcinoma，NPC）新生血管形成及生存的关系，探讨MIF对NPC患者预后的预测价值。免疫组化法检测MIF和白细胞介素8（IL-8）在组织芯片中的表达。结果：MIF（69.5%）和IL-8（56.0%）的高表达与微血管密度（IMD）、淋巴结转移密切相关。单因素分析显示，MIF、IL-8高表达和IMD高水平与鼻咽癌患者的总生存期和疾病特异性生存期相关，而多因素分析显示，只有血管生成和淋巴结状态与鼻咽癌患者的生存期相关。结论：MIF可能通过上调IL-8的表达，促进NPC淋巴结的新生血管生成，从而促进NPC淋巴结转移。外科肿瘤学杂志2010;102：844-851。(C)2010 Wiley-Liss，Inc.
Background and Objectives: We aim at the association of macrophage migration inhibitory factor (MIF) with neovascularization and survival of nasopharyngeal carcinoma (NPC), and determine whether MIF is a valuable prognostic predictor for NPC patients.Methods: One hundred and forty one cases of NPC and 25 normal tissues of nasopharynx were collected. The expression of MIF and interleukin 8 (IL-8) was evaluated in tissues microarray by immunostaining. Intratumoral microvessel density (IMD) in relation to immunostainings and clinicopathological factors were analyzed statistically as well as the follow-up data of patients.Results: High-expression of both MIF (69.5%) and IL-8 (56.0%) were significantly associated with increased microvessels and lymph node metastasis. High-expression of MIF, IL-8 and higher level of IMD were correlated with either patients' overall survival or disease-specific survival in univariate analysis, but only angiogenesis and lymph node status exhibited in relation to survival of patients as independent prognostic factor of NPC by multivariate analysis. In addition, high-expression of MIF and higher level of IMD were closely associated with locoregional failure of NPC patients.Conclusions: MIF may contribute to lymph node metastasis in NPC by inducing angiogenesis through the way of upregulation of IL-8 expression in an autocrine EBV-independent pathway. J. Surg. Oncol. 2010;102:844-851. (C) 2010 Wiley-Liss, Inc.