Plasma irisin level associated with hemodynamic parameters and predict clinical outcome in patients with acute pulmonary embolism
Plasma irisin level associated with hemodynamic parameters and predict clinical outcome in patients with acute pulmonary embolism
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血浆鸢尾素水平与血流动力学参数相关并预测急性肺栓塞患者的临床结果
DOI：
10.1016/j.rmed.2020.106072
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发表时间：
2020
影响因子：
4.3
通讯作者：
Bingxiang Wu
中科院分区：
文献类型：
--
作者：
Na Sun;Youli Fan;Jiaxue Chang;Yiqiang Chen;Xuan Gao;Hongru Sun;Zhuozhong Wang;Xia Gu;Jinwei Tian;Yingzi Zhao;Bo Yu;Jinwei Tian;Bingxiang Wu
摘要本研究旨在探讨急性肺栓塞（APE）患者血浆鸢尾素水平与血流动力学参数的相关性，并评价血浆鸢尾素水平对临床预后的预测价值。方法前瞻性招募86例成年APE患者。所有入选患者均使用ELISA试剂盒检测血浆鸢尾素水平。根据不同血浆鸢尾素水平评估基线临床特征、血流动力学参数和预后情况。结果根据鸢尾素水平中位数将APE患者分为高鸢尾素组（≥6.9 μg/ml）和低鸢尾素组（≥6.9 μg/ml）。结论血浆鸢尾素水平与APE患者血流动力学参数呈负相关。低鸢尾素组患者的临床恶化事件发生率显著高于对照组，在多因素分析中可作为临床预后的独立预测因子。
AbstractBackground The purpose of the present study is to investigate the correlation of plasma irisin level and hemodynamic parameters in patients with acute pulmonary embolism (APE) and to estimate clinical outcome prediction value of plasma irisin level. Methods We prospectively recruited 86 adult patients with APE in the present study. All recruited patients conduct measurement of plasma irisin levels using ELISA kits. Baseline clinical characteristics, hemodynamic parameters and prognostic conditions were evaluated according to different plasma irisin levels. Results According to median values of irisin levels, APE patients were divided into high irisin group (irisin≥6.9 μg/ml) and low irisin group (irisinConclusion Plasma irisin level was negatively correlated with hemodynamic parameters in patients with APE. Low irisin group patients had significantly higher clinical worsening event rate and could be the independent predictor of clinical outcome in multivariate analysis.