ABNORMAL EXPRESSION OF CLASS-II MHC ANTIGENS IN PLACENTAE FROM PATIENTS WITH PEMPHIGOID GESTATIONIS - ANALYSIS OF CLASS-II MHC SUBREGION PRODUCT EXPRESSION
ABNORMAL EXPRESSION OF CLASS-II MHC ANTIGENS IN PLACENTAE FROM PATIENTS WITH PEMPHIGOID GESTATIONIS - ANALYSIS OF CLASS-II MHC SUBREGION PRODUCT EXPRESSION
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DOI：
10.1016/0143-4004(88)90075-6
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发表时间：
1988-01-01
期刊：
影响因子：
3.8
通讯作者：
STIRRAT, GM
中科院分区：
文献类型：
--
作者：
BORTHWICK, GM;HOLMES, RC;STIRRAT, GM
Abnormal expression of class II MHC antigens was consistently observed in an immunohistological study on placentae from patients with pemphigoid gestationis. The area in all the placentae was the chorionic villi adjacent to the maternal decidua. The villous stroma, and in some cases the chorionic fetal endothelium, had abnormal expression of class II MHC antigens. Monoclonal antibodies specific for the class II MHC subregion products (DR, DP and DQ) were used to analyse the class II MHC antigen expression. Differential expression of the class II MHC subregion products was observed on the villous stroma and chorionic fetal endothelium; DR and DP were always expressed but DQ in some cases was heterogeneous. This abnormal expression of class II MHC antigens may reflect an immunological attack on the placenta in pemphigoid gestationis.
