Cryptosporidium parvum: Intensity of infection and oocyst excretion patterns in healthy volunteers
Cryptosporidium parvum: Intensity of infection and oocyst excretion patterns in healthy volunteers
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DOI：
10.1093/infdis/173.1.232
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发表时间：
1996-01-01
影响因子：
6.4
通讯作者：
DuPont, HL
中科院分区：
文献类型：
--
作者：
Chappell, CL;Okhuysen, PC;DuPont, HL
关于人类隐孢子虫感染的数据来源于旅行者、社区和日托中心的爆发以及人类免疫缺陷病毒感染者。此外，在29名抗体阴性的健康成年志愿者中进行的实验感染产生了关于C.微小梭菌（爱荷华州株），在该报告中，低接种量足以导致18人感染和7人患病。为了进一步确定该人群的感染持续时间和强度，对18名受试者的卵囊脱落模式进行了调查感染C.小的卵囊定量显示，在感染过程中，患有腹泻病的志愿者（n = 7）比没有腹泻的志愿者排出更多的卵囊（n = 11; P <0.05）。有症状的受试者更可能连续几天排出卵囊。此外，在攻毒剂量和总排出卵囊之间观察到统计学上不显著的反向趋势（r（2）= .330，P = .136）。这种矛盾可能与受体饱和或高接种量对细胞、寄生虫或两者的毒性作用有关。
Data about human Cryptosporidium parvum infection have originated from travelers, community and day care center outbreaks, and persons infected with the human immunodeficiency virus, In addition, experimental infection in 29 antibody-negative, healthy, adult volunteers generated information on the dose-infection response of C. parvum (Iowa strain), In that report, low inocula were sufficient to cause infection in 18 and illness in 7 persons, To further define the duration and intensity of infection in this population, oocyst shedding patterns were investigated in the 18 subjects infected with C. parvum. Oocyst quantitation revealed that volunteers with diarrheal illness (n = 7) excreted more oocysts over the course of the infection than did volunteers without diarrhea (n = 11; P < .05). Symptomatic subjects were more likely to shed oocysts on consecutive days, Further, a statistical nonsignificant inverse trend (r(2) = .330, P = .136) was seen between challenge dose and total excreted oocysts, This paradox may relate to receptor saturation or a toxic effect on cells, parasites, or both afforded by a high inoculum.