Role of reactive oxygen species (ROS) in apoptosis induction
Role of reactive oxygen species (ROS) in apoptosis induction
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DOI：
10.1023/a:1009616228304
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发表时间：
2000-11-01
期刊：
影响因子：
7.2
通讯作者：
Levi-Schaffer, F
中科院分区：
文献类型：
--
作者：
Simon, HU;Haj-Yehia, A;Levi-Schaffer, F
在生理和病理条件下，活性氧簇(ROS)和线粒体在诱导细胞凋亡中起着重要作用。有趣的是，线粒体既是ROS的来源，也是ROS的靶。细胞色素c从线粒体释放，触发caspase激活，似乎在很大程度上是由直接或间接的ROS作用介导的。另一方面，ROS也具有抗细胞凋亡的作用。本文就ROS在细胞凋亡，尤其是炎性细胞中的调控作用作一综述。
Reactive oxygen species (ROS) and mitochondria play an important role in apoptosis induction under both physiologic and pathologic conditions. Interestingly, mitochondria are both source and target of ROS. Cytochrome c release from mitochondria, that triggers caspase activation, appears to be largely mediated by direct or indirect ROS action. On the other hand, ROS have also anti-apoptotic effects. This review focuses on the role of ROS in the regulation of apoptosis, especially in inflammatory cells.