Immunostimulation by plant polyphenols:: A relationship between tumor necrosis factor-α production and tannin structure
Immunostimulation by plant polyphenols:: A relationship between tumor necrosis factor-α production and tannin structure
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DOI：
10.1016/s0960-894x(99)00110-9
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发表时间：
1999-04-05
影响因子：
2.7
通讯作者：
Scheuchenzuber, WJ
中科院分区：
文献类型：
--
作者：
Feldman, KS;Sahasrabudhe, K;Scheuchenzuber, WJ
已证明天然存在的杀肿瘤鞣花单宁马桑苷A能够刺激人外周血单核细胞分泌IL-1 β和TNF-α。对单体没食子单宁β-D-五没食子酰葡萄糖和合成的二聚没食子单宁-鞣花单宁杂合物的伴随研究表明，TNF-α而不是IL-1 β是单宁介导的体内抗肿瘤作用的病原体，与早期的提议相反。(C)1999 Elsevier Science Ltd.保留所有权利。
The ability of the naturally occurring tumoricidal ellagitannin coriariin A to stimulate secretion of both IL-I beta and TNF-alpha from human peripheral blood mononuclear cems has been demonstrated. Companion studies with the monomeric gallotannin beta-D-pentagalloylglucose and a synthesized dimeric gallotannin-ellagitannin hybrid suggest that TNF-alpha rather than IL-I beta is the causative agent in tannin-mediated antitumor action in vivo, in contrast to an earlier proposal. (C) 1999 Elsevier Science Ltd. All rights reserved.