METABOLISM OF GERANIOL AND LINALOOL IN THE RAT AND EFFECTS ON LIVER AND LUNG MICROSOMAL-ENZYMES
METABOLISM OF GERANIOL AND LINALOOL IN THE RAT AND EFFECTS ON LIVER AND LUNG MICROSOMAL-ENZYMES
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DOI：
10.3109/00498258409151425
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发表时间：
1984-01-01
期刊：
影响因子：
1.8
通讯作者：
MADYASTHA, KM
中科院分区：
文献类型：
--
作者：
CHADHA, A;MADYASTHA, KM
从大鼠口服香叶醇后尿液中分离出的代谢产物有：香叶酸、3-羟基香茅酸、8-羟基香叶醇、8-羧基香叶醇和Hildebrandt酸。从口服芳樟醇后大鼠尿液中分离的代谢物为8-羟基芳樟醇和8-羧基芳樟醇。用香叶醇或芳樟醇喂养大鼠3天后，肝微粒体细胞色素P-450增加。在6天的治疗过程中，NADH和NADPH细胞色素c还原酶活性没有显着变化。口服这2种萜类化合物不影响任何肺微粒体参数测量。
Metabolites isolated from the urine of rats after oral administration of geraniol were: geranic acid, 3-hydroxy-citronellic acid, 8-hydroxy-geraniol, 8-carboxy-geraniol and Hildebrandt acid. Metabolites isolated from urine of rats after oral administration of linalool were 8-hydroxy-linalool and 8-carboxy-linalool. After 3 days of feeding rats with geraniol or linalool, liver microsomal cytochrome P-450 was increased. NADH- and NADPH-cytochrome c reductase activities were not significantly changed during the 6 days of treatment. Oral administration of these 2 terpenoids did not affect any lung microsomal parameter measured.