A specialized forebrain circuit for vocal babbling in the juvenile songbird
A specialized forebrain circuit for vocal babbling in the juvenile songbird
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DOI：
10.1126/science.1155140
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发表时间：
2008-05-02
期刊：
影响因子：
56.9
通讯作者：
Fee, Michale S.
中科院分区：
文献类型：
--
作者：
Aronov, Dmitriy;Andalman, Aaron S.;Fee, Michale S.
幼年动物参与各种各样的探索行为对神经回路和成年运动控制的发展至关重要，然而这些行为的神经基础在很大程度上是未知的。幼年鸣禽会发出次鸣声——一系列类似于人类咿呀学语的原始声音。我们发现，斑胸草雀的亚鸣声产生不需要HVC（高发声中枢），这是成年鸟类歌唱的关键运动前区域，但确实需要LMAN（尼指外侧大细胞核），这是一个参与学习但不参与成年歌唱的前脑核。在咿呀学语的过程中，LMAN的神经元在快速的时间尺度上表现出与声音输出的运动前相关性。因此，青少年鸣叫是由一种不同于产生成人行为的回路驱动的——这种分离可能普遍存在于其他发育中的运动系统中。
Young animals engage in variable exploratory behaviors essential for the development of neural circuitry and adult motor control, yet the neural basis of these behaviors is largely unknown. Juvenile songbirds produce subsong- a succession of primitive vocalizations akin to human babbling. We found that subsong production in zebra finches does not require HVC ( high vocal center), a key premotor area for singing in adult birds, but does require LMAN ( lateral magnocellular nucleus of the nidopallium), a forebrain nucleus involved in learning but not in adult singing. During babbling, neurons in LMAN exhibited premotor correlations to vocal output on a fast time scale. Thus, juvenile singing is driven by a circuit distinct from that which produces the adult behavior- a separation possibly general to other developing motor systems.