Statistical Tests with Historical Controls
Statistical Tests with Historical Controls
复制标题
历史对照的统计检验
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
D. Colin
中科院分区：
文献类型：
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作者：
D. Krewski;R. Smythe;A. Dewanji;D. Colin
致癌物生物测定涉及将实验室动物暴露于一种或多种水平的供试品，评价给药组相对于未暴露对照组的肿瘤发生率（Bickis和Krewski，1985 a）。未给药动物与给药动物同时进行试验，并在相同实验室中相同条件下饲养。由于并行对照动物在所有方面均与暴露动物相似（试验化学品处理除外），因此普遍认为它们构成了比较暴露组的最适当参照组。
Carcinogen bioassay involves exposure of laboratory animals to one or more levels of the test substance, with tumor occurrence rates in the treated groups evaluated relative to those in unexposed controls (Bickis and Krewski, 1985a). The untreated animals are maintained on test at the same time as the treated animals and housed under the same conditions in the same laboratory. Because the concurrent controls are thus similar to the exposed animals in all respects except for treatment with the test chemical, it is generally agreed that they constitute the most appropriate reference group against which to compare the exposed groups.