Impact of age older than 60 years in living donor liver transplantation
Impact of age older than 60 years in living donor liver transplantation
复制标题
DOI：
10.1097/01.tp.0000269103.87633.06
复制
发表时间：
2007-07-27
期刊：
影响因子：
6.2
通讯作者：
Uemoto, Shinji
中科院分区：
文献类型：
--
作者：
Kuramitsu, Kaori;Egawa, Hiroto;Uemoto, Shinji
背景活体肝移植（LDLT）近年来扩展到成人，最近扩展到老年患者。分析供体年龄的影响、老年LDLT受体术前危险因素的分析以及老年和年轻受体之间并发症发生率的比较。受试者包括1996年10月至2005年12月在京都大学医院接受LDLT的患者。23名供体年龄在60岁或以上，411名年龄小于60岁。52例受者年龄≥ 60岁，410例年龄<60岁。供体术后肝功能恢复和受体/移植物存活率不受供体年龄的影响。60岁以上献血者住院时间较60岁以下献血者长（P = 0.02）。60岁以上受者的5年生存率为78.7%，年轻受者为69.3%（P = 0.26）。在影响受体存活率的术前危险因素中，暴发性肝功能衰竭和术前是否在重症监护室有显著性差异（P
Background. Living donor liver transplantation (LDLT) was extended to adults in recent years and more recently to older patients. The impact of donor age, analysis of preoperative risk factors for older LDLT recipients, and comparison of the complication rate between older and younger recipients were analyzed.Methods. Subjects included patients who underwent LDLT at Kyoto University Hospital from October 1996 to December 2005. Twenty-three donors were 60 years of age or older, and 411 were younger than 60 years of age. Fifty-two recipients were 60 years of age or older and 410 were younger than 60 years of age.Results. Postoperative recovery of liver function for donors and recipient/graft survival were not influenced by donor age. Hospital stay was longer in the donors 60 years of age or older than those younger than 60 years of age (P=0.02). The 5-year survival rates were 78.7% in recipients 60 years of age or older and 69.3% in younger recipients (P=0.26). Among preoperative risk factors for recipient survival rate, fulminant hepatic failure and preoperative status in the intensive care unit were significant (P