Detection of low back pain using pH level-dependent imaging of the intervertebral disc using the ratio of R1ρ dispersion and -OH chemical exchange saturation transfer (RROC).
Detection of low back pain using pH level-dependent imaging of the intervertebral disc using the ratio of R1ρ dispersion and -OH chemical exchange saturation transfer (RROC).
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DOI：
10.1002/mrm.25186
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发表时间：
2015-03
影响因子：
3.3
通讯作者：
Li D
中科院分区：
文献类型：
--
作者：
Liu Q;Tawackoli W;Pelled G;Fan Z;Jin N;Natsuaki Y;Bi X;Gart A;Bae H;Gazit D;Li D
低pH值与椎间盘（IVD）产生的腰痛（LBP）相关。本工作的目的是开发一种体内pH水平依赖的磁共振成像（MRI）方法，用于检测椎间盘源性LBP，而不使用外源性造影剂。R1ρ分散和化学交换饱和转移（CEST）（RROC）的比率用于IVD的pH水平依赖性成像，同时消除不稳定质子浓度的影响。该技术通过数值模拟和对体模和离体猪脊柱的研究进行了验证。4例男性（42.8 ± 18.3岁）和2例女性（55.5 ± 2.1岁）腰椎间盘突出症患者在3.0T MR扫描仪上进行了椎间盘造影检查。使用配对t检验将RROC测量结果与椎间盘造影结果进行比较。模拟和体模结果表明，RROC是一个浓度无关和pH值依赖的技术。猪脊柱研究结果发现，较高的RROC值与较低的pH水平相关。椎间盘造影诊断为疼痛的患者RROC值显著高于阴性者（P < 0.05）。RROC成像是一种很有前途的pH值依赖性MRI技术，有可能成为一种无创成像工具，以检测体内疼痛的IVD。
Low pH is associated with intervertebral disc (IVD)-generated low back pain (LBP). The purpose of this work was to develop an in vivo pH level-dependent magnetic resonance imaging (MRI) method for detecting discogenic LBP, without using exogenous contrast agents. The ratio of R1ρ dispersion and chemical exchange saturation transfer (CEST) (RROC) was used for pH-level dependent imaging of the IVD while eliminating the effect of labile proton concentration. The technique was validated by numerical simulations and studies on phantoms and ex vivo porcine spines. Four male (ages 42.8 ± 18.3) and two female patients (ages 55.5 ± 2.1) with LBP and scheduled for discography were examined with the method on a 3.0 Tesla MR scanner. RROC measurements were compared with discography outcomes using paired t-test. Simulation and phantom results indicated RROC is a concentration independent and pH level-dependent technique. Porcine spine study results found higher RROC value was related to lower pH level. Painful discs based on discography had significant higher RROC values than those with negative diagnosis (P < 0.05). RROC imaging is a promising pH level dependent MRI technique that has the potential to be a noninvasive imaging tool to detect painful IVDs in vivo.