SELENIUM IN FORAGE CROPS AND CANCER MORTALITY IN UNITED-STATES COUNTIES
SELENIUM IN FORAGE CROPS AND CANCER MORTALITY IN UNITED-STATES COUNTIES
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DOI：
10.1080/00039896.1991.9937427
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发表时间：
1991-01-01
期刊：
影响因子：
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通讯作者：
ALLAWAY, WH
中科院分区：
文献类型：
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作者：
CLARK, LC;CANTOR, KP;ALLAWAY, WH
硒状态对癌症风险的潜在保护作用已在动物和表皮研究中进行了研究。 本生态研究采用加权最小二乘回归法调查了美国县饲料硒状况与特定地点和性别县癌症死亡率（1950-1969年）之间的关系。 在仅限于农村县的模型中，观察到肺癌、直肠癌、膀胱癌、食管癌和宫颈癌的一致性、显著性（p <0.01）负相关，在所有县的模型中，观察到肺癌、乳腺癌、直肠癌、膀胱癌、食管癌和子宫体癌的一致性、显著性（p <0.01）负相关。 在农村县模型中没有观察到一致的显着正相关。 这种负相关的显著一致性加强了低硒状态与癌症死亡风险增加之间因果关系的可能性。
The potential protective effect of selenium status on the risk of developing cancer has been examined in animal and epidermiologic studies. This ecological study investigated the association between U.S. county forage selenium status and site- and sex-specific county cancer mortality rates (1950-1969) using weighted least squares regression. Consistent, significant (p < .01) inverse associations were observed for cancers of the lung, rectum, bladder, esophagus, and cervix in a model limited to rural counties and for cancers of the lung, breast, rectum, bladder, esophagus, and corpus uteri in a model of all counties. No consistent significant positive associations were observed in the rural county models. This remarkable degree of consistency for the inverse associations strengths the likelihood of a causal relationship between low selenium status and an increased risk of cancer mortality.