Implantable wireless powered light emitting diode (LED) for near-infrared photoimmunotherapy: device development and experimental assessment in vitro and in vivo.
Implantable wireless powered light emitting diode (LED) for near-infrared photoimmunotherapy: device development and experimental assessment in vitro and in vivo.
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DOI：
10.18632/oncotarget.25068
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发表时间：
2018-04-13
期刊：
影响因子：
--
通讯作者：
Ogawa M
中科院分区：
文献类型：
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作者：
Nakajima K;Kimura T;Takakura H;Yoshikawa Y;Kameda A;Shindo T;Sato K;Kobayashi H;Ogawa M
本研究的目的是开发和评估一种新型的植入式，无线供电，发光二极管（LED）的近红外光免疫治疗（NIR-PIT）。NIR-PIT是最近开发的癌症疗法，其使用NIR光和抗体-光敏剂缀合物，并且能够诱导癌症特异性细胞死亡。由于光穿透深度有限，目前无法治疗深部组织中的肿瘤。使用植入式LED可能会克服这一限制。无线LED系统能够通过使用符合人体使用限制的低磁场，在距离发射器线圈20厘米的距离内发射近红外光。结果表明，LED系统能够在体外杀死肿瘤细胞，并抑制植入荷瘤小鼠的肿瘤生长。结果表明，所提出的植入式无线LED系统能够抑制体内肿瘤生长。这些结果令人鼓舞，因为像这里开发的无线LED系统可能是治疗人类深部肿瘤的可能解决方案。在这一领域的进一步研究将是重要的。研制了一种植入式LED系统。它包括一个LED胶囊，包括两个LED源和一个接收器线圈，与外部线圈和电源耦合。无线能量传输是通过电磁感应来保证的。通过使用EGFR表达细胞和HER 2表达细胞在体外测试该系统。该系统还在荷瘤小鼠体内进行了测试。
The aim of this study was to develop and assess a novel implantable, wireless-powered, light-emitting diode (LED) for near-infrared photoimmunotherapy (NIR-PIT). NIR-PIT is a recently developed cancer therapy that uses NIR light and antibody-photosensitizer conjugates and is able to induce cancer-specific cell death. Due to limited light penetration depth it is currently unable to treat tumors in deep tissues. Use of implanted LED might potentially overcome this limitation. The wireless LED system was able to emit NIR light up to a distance of 20 cm from the transmitter coil by using low magnetic fields as compliant with limits for use in humans. Results indicated that the LED system was able to kill tumor cells in vitro and to suppress tumor growth in implanted tumor-bearing mice. Results indicated that the proposed implantable wireless LED system was able to suppress tumor growth in vivo. These results are encouraging as wireless LED systems such as the one here developed might be a possible solution to treat tumors in deep regions in humans. Further research in this area would be important. An implantable LED system was developed. It consisted of a LED capsule including two LED sources and a receiver coil coupled with an external coil and power source. Wireless power transmission was guaranteed by using electromagnetic induction. The system was tested in vitro by using EGFR-expressing cells and HER2-expressing cells. The system was also tested in vivo in tumor-bearing mice.