Effects of ipsilateral rostral pontine reticular lesions on retention of classically conditioned nictitating membrane and eyelid responses
Effects of ipsilateral rostral pontine reticular lesions on retention of classically conditioned nictitating membrane and eyelid responses
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同侧脑桥头端网状病变对经典条件瞬膜和眼睑反应保留的影响
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
Richard F. Thompson
中科院分区：
文献类型：
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作者：
D. Lavond;D. McCormick;G. A. Clark;David T. Holmes;Richard F. Thompson
来自训练有素的兔子的脑桥网状结构的神经单元记录显示了音调诱发的起始反应（CS），暗示了喷气起始反应（UCS），以及与学习反应的地形相似的单元活动的增加。当这个相同的区域被单侧电解损伤破坏时（在另一组动物中），学习反应的保留被取消，但反射反应基本上没有变化。由于最近的一项研究（麦考密克，拉旺德，克拉克，Kettner，上升，和汤普森，1981年）表明，单侧小脑病变也产生一个完全的和选择性的取消CR，CR不能恢复与再训练，这些研究结果进行了讨论，在一个共同的电路，编码的痕迹短延迟经典条件反射的横纹肌反应。
Neural unit recordings from the pontine reticular formation in well-trained rabbits show a tone-evoked onset response (CS), a suggestion of an airpuff onset response (UCS), and an increase in unit activity that is similar to the topography of the learned response. When this same area is destroyed by unilateral electrolytic lesions (in another group of animals), retention of the learned response is abolished but the reflex response is essentially unchanged. Since a recent study (McCormick, Lavond, Clark, Kettner, Rising, & Thompson, 1981) has shown that unilateral cerebellar lesions also produce a complete and selective abolition of the CR, and the CR cannot be reinstated with retraining, these findings are discussed in terms of a common circuitry that encodes the engram for short-delay classical conditioning of striated muscle responses.