Non-Canonical Functions of Splicing Factors in RNA Metabolism
Non-Canonical Functions of Splicing Factors in RNA Metabolism
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DOI：
10.1080/07352689.2020.1857602
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发表时间：
2020-11
影响因子：
6.9
通讯作者：
Xiao Han;Yi Lin;Xin-Qi Gao;Xiu-Ling Wang
中科院分区：
文献类型：
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作者：
Xiao Han;Yi Lin;Xin-Qi Gao;Xiu-Ling Wang
摘要非编码RNA（ncRNA），如microRNA（miRNAs）、long ncRNA（lncRNA）和circular RNA（circRNA）等，通过多种方式参与植物的生长发育和对环境信号的响应。剪接因子对于前体信使RNA（pre-mRNAs）剪接和选择性剪接至关重要。引人注目的是，在过去的几年里，越来越多的研究表明剪接因子将剪接与其他过程偶联，例如ncRNA生物合成，核保留和各种RNA的细胞质输出，甚至翻译。本文综述了剪接因子在植物ncRNA加工、RNA保留、RNA输出和翻译中的非经典功能。
Abstract Noncoding RNA (ncRNA), such as microRNA (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs) play roles in plant growth, development, and response to environmental cues via diverse manners. Splicing factors are critical for precursor messenger RNAs (pre-mRNAs) splicing and alternative splicing. Strikingly, over the past few years, an increasing number of studies demonstrated that splicing factors couple splicing to other processes, such as ncRNA biogenesis, nuclear retention, and cytoplasmic export of various RNAs, and even translation. Here, we review the current status of the noncanonical functions of splicing factors in the ncRNAs processing, retention and export of RNAs, and translation in plants.