PRESSURE MEASUREMENTS IN THE NORMAL AND OCCLUDED RABBIT MAXILLARY SINUS
PRESSURE MEASUREMENTS IN THE NORMAL AND OCCLUDED RABBIT MAXILLARY SINUS
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DOI：
10.1288/00005537-199506000-00002
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发表时间：
1995-06-01
期刊：
影响因子：
2.6
通讯作者：
GANNON, PJ
中科院分区：
文献类型：
--
作者：
SCHARF, KE;LAWSON, W;GANNON, PJ
上颌窦口的阻塞被认为是上颌窦炎发病的关键因素。在这项研究中，作者确定了口阻塞对兔上颌窦压力的影响，与大多数人一样，兔上颌窦只有一个口。我们比较了麻醉成年动物在自主呼吸时正常和阻塞上颌窦和鼻腔的压力。对经鼻呼吸的家兔和经鼻呼吸和气管切开的动物的窦口开放和窦口闭塞的窦口进行了连续的压力测量，窦口开放的窦口压力曲线与呼吸周期同步。鼻腔和鼻窦的吸气压和呼气压均为等压。窦口闭塞的窦最初形成正压，随后在20至50分钟内形成负压，达到-28.2 +/- 7.3 mm H2O（平均值+/-标准差[SD]）的亚大气压平台。这些发现可能有助于更好地理解窦口阻塞在人类上颌窦炎发病机制中的作用。
Occlusion of the maxillary ostium is considered to be a key factor in the pathogenesis of maxillary sinusitis. in this study, the authors determined the effect of ostial occlusion on pressure in the rabbit maxillary sinus which, like most humans, has only one ostium, We compared pressures in the normal and occluded maxillary sinus and the nasal cavity during spontaneous breathing in anesthetized adult animals. Serial pressure measurements were obtained from sinuses with patent ostia in nasal-breathing rab bits and with occluded ostia in both nasal-breathing and tracheotomized animals.Sinuses with patent ostia showed pressure curves synchronous with the respiratory cycle. Inspiratory and expiratory pressures in the nasal cavity and the sinus were isobaric. Sinuses with occluded ostia initially developed a positive pressure followed by a negative pressure that reached a subatmospheric plateau of-28.2 +/- 7.3 mm H2O (mean +/- standard deviation [SD]) within 20 to 50 minutes.This is the first quantitative study of sinus pressures using the rabbit as an animal model. The findings may contribute to a better understanding of the role of ostial occlusion in the pathogenesis of maxillary sinusitis in humans.