Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
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DOI：
10.1038/6368
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发表时间：
1999-03-01
影响因子：
25
通讯作者：
Gage, FH
中科院分区：
文献类型：
--
作者：
van Praag, H;Kempermann, G;Gage, FH
暴露在丰富的环境中会增加成年啮齿动物齿状回的神经发生。然而，环境丰富通常包括许多组成部分，如扩大学习机会、增加社会互动、更多的体育活动和更大的住房。我们试图通过将成年小鼠分配到不同的条件下来分离组件：水迷宫学习组(学习者)，游泳时间挂钩控制组(游泳者)，自愿车轮跑步组(跑步者)，以及丰富(丰富)和标准住房(控制)组。迷宫训练和负重游泳对BrdU阳性细胞数均无影响。然而，跑步使存活的新生细胞数量翻了一番，数量与浓缩条件相似。我们的发现表明，自愿运动足以增强成年小鼠齿状回的神经发生。
Exposure to an enriched environment increases neurogenesis in the dentate gyrus of adult rodents. Environmental enrichment, however, typically consists of many components, such as expanded learning opportunities, increased social interaction, more physical activity and larger housing. We attempted to separate components by assigning adult mice to various conditions: water-maze learning (learner), swim-time-yoked control (swimmer), voluntary wheel running (runner), and enriched (enriched) and standard housing (control) groups. Neither maze training nor yoked swimming had any effect on bromodeoxyuridine (BrdU)-positive cell number. However, running doubled the number of surviving newborn cells, in amounts similar to enrichment conditions. Our findings demonstrate that voluntary exercise is sufficient for enhanced neurogenesis in the adult mouse dentate gyrus.