Disorders of placental villous maturation in fetal death
Disorders of placental villous maturation in fetal death
复制标题
DOI：
10.1515/jpm-2020-0030
复制
发表时间：
2020-05-01
影响因子：
2.4
通讯作者：
Hsu, Chaur-Dong
中科院分区：
文献类型：
--
作者：
Jaiman, Sunil;Romero, Roberto;Hsu, Chaur-Dong
目的：本研究的目的是确定胎儿死亡的绒毛成熟障碍的频率，并描绘其他胎盘组织病理学病变的胎儿death.Methods：这是一项回顾性观察性队列研究，2004年1月至2016年1月在Hutzel妇女医院，底特律，密歇根州，美国之间发生的妇女胎儿死亡。病例包括妊娠20周以上死亡的胎儿。胎儿死亡与先天性异常和多胎妊娠被排除在外。对照组包括无内科/产科并发症的孕妇和单胎分娩的足月新生儿（37-42周），5 min Apgar评分≥ 7分，出生体重在第10 ~ 90胎之间。胎儿死亡与（1）绒毛成熟障碍的发生率较高[44.0%（64/143）vs.1.0%（4/405），P< 0.0001，患病率为44.6;绒毛成熟延迟，22%（31/1143）;绒毛加速成熟20%（28/143）;成熟停滞4%（5/143）];（2）母体血管灌注不良病变的发生率较高[75.5%（108/143）vs. 35.7%（337/944），P
Objective: The aims of this study were to ascertain the frequency of disorders of villous maturation in fetal death and to also delineate other placental histopathologic lesions in fetal death.Methods: This was a retrospective observational cohort study of fetal deaths occurring among women between January 2004 and January 2016 at Hutzel Women's Hospital, Detroit, MI, USA. Cases comprised fetuses with death beyond 20 weeks' gestation. Fetal deaths with congenital anomalies and multiple gestations were excluded. Controls included pregnant women without medical/obstetrical complications and delivered singleton, term (37-42 weeks) neonate with 5-min Apgar score >= 7 and birthweight between the 10th and 90th percentiles.Results: Ninety-two percent (132/143) of placentas with fetal death showed placental histologic lesions. Fetal deaths were associated with (1) higher frequency of disorders of villous maturation [44.0% (64/143) vs. 1.0% (4/405), P< 0.0001, prevalence ratio, 44.6; delayed villous maturation, 22% (31/1 1 43); accelerated villous maturation, 20% (28/143); and maturation arrest, 4% (5/143)]; (2) higher frequency of maternal vascular malperfusion lesions [75.5% (108/143) vs. 35.7% (337/944), P