IMMUNOREGULATORY EFFECTS OF CIMETIDINE - INHIBITION OF SUPPRESSOR-CELL EFFECTOR FUNCTION INVIVO
IMMUNOREGULATORY EFFECTS OF CIMETIDINE - INHIBITION OF SUPPRESSOR-CELL EFFECTOR FUNCTION INVIVO
复制标题
DOI：
10.3109/08923978809041424
复制
发表时间：
1988-01-01
影响因子：
3.3
通讯作者：
CLEVELAND, RP
中科院分区：
文献类型：
--
作者：
KUMAR, A;CLEVELAND, RP
在一个充分研究的接触性超敏反应小鼠模型中，检测了西咪替丁对抑制细胞效应器功能的影响。静脉接种BALB/c小鼠与DNP偶联的同系脾细胞诱导DNP特异性抑制细胞的产生，这通过将脾和淋巴结细胞转移到幼稚的同系受体后用1-氟-2，4-二硝基苯（DNFB）接触致敏后耳肿胀的减少来证明。西咪替丁治疗的小鼠谁也收到抑制细胞消除抑制细胞活性的表现，通过与DNFB接触致敏后的正常免疫反应的发展进行测量。虽然所有接受西咪替丁的组均显示迟发型超敏反应恢复，但在第5天（攻毒当天）给予50 mg/kg西咪替丁时观察到最大效应。这些结果表明，除了其先前描述的抑制作用，抑制细胞诱导，西咪替丁也能够抑制细胞效应功能。组胺在这两个过程中在体内的参与也建议。
The effcts of cimetidine upon suppressor cell effector function in a well-studied murine model of contact hypersensitivity were examined. Intravenous inoculation of BALB/c mice with DNP-coupled syngeneic spleen cells induced the production of DNP-specific suppressor cells which was demonstrated by a reduction in ear swelling after contact sensitization with 1-fluoro-2, 4-dinitrobenzene (DNFB) following transfer of spleen and lymph node cells to naive syngeneic recipients. Cimetidine treatment of mice who had also received suppressor cells eliminated the manifestation of suppressor cell activity as measured by the development of normal immunologic response following contact sensitization with DNFB. While all the groups receiving cimetidine showed restoration of delayed hypersensitivity, the maximum effect was seen when 50 mg/kg of cimetidine was administered on Day 5 (day of challenge). These results indicate that, in addition to its previously described inhibitory role in suppressor cell induction, cimetidine is also capable of inhibiting suppressor cell effector function. The involvement of histamine in both these processes in vivo is also suggested.