Influence of additive hyaluronic acid on the lubricating ability in the temporomandibular joint
Influence of additive hyaluronic acid on the lubricating ability in the temporomandibular joint
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DOI：
10.1002/jbm.a.30078
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发表时间：
2004-07-01
影响因子：
4.9
通讯作者：
Tanne, K
中科院分区：
文献类型：
--
作者：
Kawai, N;Tanaka, E;Tanne, K
在滑液中，透明质酸(HA)是关节润滑的重要成分，从而防止摩擦。HA和关节摩擦之间的关系还没有明确确立。本研究旨在探讨羟基磷灰石(HA)的应用对颞下颌关节摩擦系数的影响。在测量了10个完整猪关节的摩擦系数后，考察了磷酸盐缓冲盐水(PBS)洗涤和纱布洗涤的后续效果以及HA的应用。与完整关节相比，PBS洗涤和纱布洗涤后的摩擦系数明显增大。随后添加HA后，摩擦系数显著降低(50-75%)。然而，它并没有恢复到与完整关节相同的值。扫描电子显微镜观察显示，PBS洗涤后关节软骨无定形层仍完整，而纱布擦洗后关节软骨无定形层部分塌陷。综上所述，在本研究的实验条件下，HA的加入确实降低了摩擦系数；与临床条件的相关性以及体内治疗效果的持续时间有待进一步研究。(C)2004年威利期刊公司。
In synovial fluid, hyaluronic acid (HA) is an essential component for the lubrication of joints, thus preventing friction. The relationship between HA and joint friction is not unambiguously established yet. In the present study, the effect of the application of HA on the frictional coefficient in the temporomandibular joint was evaluated. After measuring the frictional coefficient in intact porcine joints (n = 10), the subsequent effect of phosphate-buffered saline (PBS) washing and gauze scouring and the application of HA was examined. Compared with the intact joint, the frictional coefficient was significantly larger after PBS washing and gauze scouring. Subsequent application of HA resulted in a significant decrease (50-75%) of the frictional coefficient. However, it did not recover to the same value as in the intact joints. Observations by scanning electron microscopy showed that after PBS washing, the amorphous layer of the articular cartilage was still intact, whereas it was partially collapsed after gauze scouring. In conclusion, the addition of HA did reduce the coefficient of friction under the experimental conditions in this study; the relevance to the clinical condition and the duration of the treatment effect in vivo require further investigation. (C) 2004 Wiley Periodicals, Inc.