Quality of life and emotional responses in cadaver and living related renal transplant recipients
Quality of life and emotional responses in cadaver and living related renal transplant recipients
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DOI：
10.1093/ndt/17.12.2204
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发表时间：
2002-12-01
影响因子：
6.1
通讯作者：
Newman, SP
中科院分区：
文献类型：
--
作者：
Griva, K;Ziegelmann, JP;Newman, SP
背景移植对活体亲属供者（LRD）和尸体（CAD）肾移植受者及其健康相关生活质量（HQoL）的具体影响很少受到关注。本研究探讨了社会人口学，医疗和心理因素在这两组中的作用。共有347名移植受者（76名LRD和271名CAD患者）完成了简表36健康调查和移植效果评估。总体而言，移植患者表现出令人满意的HQoL，特别是在情绪健康方面。发现两个移植组的HQoL水平相当。ANCOVA分析显示，LRD受者对供体的内疚感更强（P < 0.001）。多变量分析显示，仅对移植的可行性和功能的担忧预测了SF-36心理综合评分（MCS）的15.1%的方差，而年龄、收入、合并症和透析时间解释了SF-36身体综合评分（PCS）的37.8%的方差。分别对LRD和CAD患者进行的多元回归分析显示，两组之间MCS和PCS的预测因素相似。我们的研究结果表明，不同形式的移植（LRD与CAD）可能会导致不同的情绪反应，尽管没有明显的生活质量差异。特别是，内疚的感觉似乎是突出的LRD移植。
Background. The specific impact of transplantation on living related donor (LRD) and cadaver (CAD) kidney transplant recipients and their health-related quality of life (HQoL) has received little attention. This study examined the role of sociodemographic, medical and psychological factors in these two groups.Methods. A total of 347 transplant recipients (76 LRD and 271 CAD patients) completed the Short Form 36 Health Survey and Transplant Effects Questionnaire.Results. Overall, transplant patients showed satisfactory HQoL particularly with respect to emotional well being. HQoL levels were found to be equivalent in both transplant groups. ANCOVAs showed that LRD recipients expressed more guilt in relation to the donor (P < 0.001). Multivariate analysis revealed that worry about the viability and functioning of the transplant alone predicted 15.1% of the variance in the SF-36 mental composite score (MCS) whereas age, income, comorbidities and time on dialysis explained 37.8% of the variance in the SF-36 physical composite score (PCS). Multiple regression analyses performed separately for LRD and CAD patients showed that predictors of MCS and PCS between the two groups were similar.Conclusions. Our results indicate that different forms of transplantation (LRD vs CAD) may lead to different emotional responses albeit with no apparent quality of life differences. In particular, feelings of guilt appear to be prominent in LRD transplantation.