Differentiation of circulating monocytes into fibroblast-like cells.
Differentiation of circulating monocytes into fibroblast-like cells.
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DOI：
10.1007/978-1-61779-943-3_16
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Gomer, Richard H
中科院分区：
文献类型：
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作者：
Pilling, Darrell;Gomer, Richard H
单核细胞在骨髓中产生并进入血液。它们通常离开血液进入组织，然后变成巨噬细胞。在愈合的伤口中，循环中的单核细胞也会进入组织，并可以分化为成纤维细胞样细胞，称为纤维细胞，而不是成为巨噬细胞。纤维细胞也存在于与纤维化疾病相关的病变中，如充血性心力衰竭、终末期肾病和肺纤维化。我们发现，在无血清介质中培养单核细胞或含有单核细胞的白细胞制剂，可以使一些单核细胞在5天内分化为纤维细胞，这种分化被血浆蛋白血清淀粉样蛋白P抑制。
Monocytes are produced in the bone marrow and enter the blood. They generally leave the blood and enter a tissue, and then become macrophages. In healing wounds, circulating monocytes also enter the tissue and instead of becoming macrophages, can differentiate into fibroblast-like cells called fibrocytes. Fibrocytes are also present in the lesions associated with fibrosing diseases such as congestive heart failure, end stage kidney disease, and pulmonary fibrosis. We have found that culturing blood monocytes, or white blood cell preparations containing monocytes, in serum-free media permits some of the monocytes to differentiate into fibrocytes within 5 days, and that this differentiation is inhibited by the blood plasma protein serum amyloid P.