Molecular epidemiology of dengue virus type 3 in Northern South America: 2000-2005
Molecular epidemiology of dengue virus type 3 in Northern South America: 2000-2005
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DOI：
10.1016/j.meegid.2008.06.008
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发表时间：
2008-09-01
影响因子：
3.2
通讯作者：
Blair, Patrick
中科院分区：
文献类型：
--
作者：
Kochel, Tadeusz;Aguilar, Patricia;Blair, Patrick
系统发育方法用于鉴定DENV-3亚型III的遗传变异体，这些变异体可能在其在整个南美洲扩张期间或之后出现。我们对2000年至2005年间从委内瑞拉、玻利维亚、厄瓜多尔和秘鲁分离的22株DENV-3毒株的衣壳、前膜/膜和包膜基因进行了测序。系统发育分析表明，在这项研究中测序的菌株形成三个分支亚型III：一个与委内瑞拉的菌株，一个与玻利维亚的菌株和一个与厄瓜多尔和秘鲁的菌株。(C)2008 Elsevier B. V.保留所有权利。
A phylogenetic approach was used to identify genetic variants of DENV-3 subtype III that may have emerged during or after its expansion throughout South America. We sequenced the capsid, premembrane/membrane and envelope genes from 22 DENV-3 strains isolated from Venezuela, Bolivia, Ecuador and Peru between 2000 and 2005. Phylogenetic analysis showed that the isolates sequenced in this study formed three clades within subtype III: one with the isolates from Venezuela, one with the Bolivian isolates and one with the isolates from Ecuador and Peru. (C) 2008 Elsevier B.V. All rights reserved.