DHEA and DHEA-S response to acute psychosocial stress in healthy men and women
DHEA and DHEA-S response to acute psychosocial stress in healthy men and women
复制标题
DOI：
10.1016/j.biopsycho.2012.03.003
复制
发表时间：
2012-05-01
影响因子：
2.6
通讯作者：
Jonsdottir, Ingibjorg H.
中科院分区：
文献类型：
--
作者：
Lennartsson, Anna-Karin;Kushnir, Mark M.;Jonsdottir, Ingibjorg H.
本研究调查了急性心理社会压力对健康男性和女性血清 DHEA 和 DHEA-S 浓度的影响。 20 名男性和 19 名女性（年龄 30-50 岁）接受了特里尔社会压力测试 (TSST)。在压力测试之前、之后以及恢复 30 分钟后进行生理测量。在男性和女性中，对压力源的反应都观察到 DHEA 和 DHEA-S 水平显着升高。反应程度存在很大的个体差异，尤其是 DHEA，但男性和女性之间没有统计差异。研究发现 DHEA 水平的变化幅度与 ACTH、皮质醇和心率的变化幅度呈正相关。此外，这项研究的结果表明，在急性心理社会压力期间分泌 DHEA 和 DHEA-S 的能力随着年龄的增长而下降。 (C) 2012 Elsevier B.V. 保留所有权利。
This study investigates the effect of acute psychosocial stress on serum concentrations of DHEA and DHEA-S in healthy men and women. Twenty men and 19 women (age 30-50 years) underwent Trier Social Stress Test (TSST). Physiological measurements were performed before, directly after the stress test and after 30 mins of recovery. In both men and women, significantly elevated DHEA and DHEA-S levels were observed in response to the stressor. There was a large inter-individual variation in the magnitude of the response, especially for DHEA but no statistical difference between men and women. Magnitude of the change in the levels of DHEA was found to be positively associated with the magnitude of the changes in ACTH, cortisol and heart rate. Furthermore, the results of this study suggest that the capacity to secrete DHEA and DHEA-S during acute psychosocial stress declines with age. (C) 2012 Elsevier B.V. All rights reserved.