Fully closed-loop insulin delivery improves glucose control of inpatients with type 2 diabetes receiving hemodialysis
Fully closed-loop insulin delivery improves glucose control of inpatients with type 2 diabetes receiving hemodialysis
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DOI：
10.1016/j.kint.2019.03.006
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发表时间：
2019-09-01
影响因子：
19.6
通讯作者：
Hovorka, Roman
中科院分区：
文献类型：
--
作者：
Bally, Lia;Gubler, Philipp;Hovorka, Roman
血液透析患者的住院糖尿病管理构成了重大挑战。在一项随机对照临床试验的事后分析中，我们比较了全自动闭环胰岛素输注与常规护理在住院期间接受血液透析的患者中的疗效。与接受传统皮下胰岛素治疗的对照患者相比，接受闭环胰岛素输送的患者将动态血糖监测仪处于5.6-10.0 mmol/l目标范围内的时间比例显着增加了37.6%，而不会增加低血糖的风险。因此，闭环胰岛素输注提供了一种新的方法，可以在这一脆弱的患者群体中实现有效和安全的血糖控制。
Inpatient diabetes management of those on hemodialysis poses a major challenge. In a post hoc analysis of a randomized controlled clinical trial, we compared the efficacy of fully automated closed-loop insulin delivery vs. usual care in patients undergoing hemodialysis while in hospital. Compared to control patients receiving conventional subcutaneous insulin therapy, those patients receiving closed-loop insulin delivery significantly increased the proportion of time when a continuous glucose monitor was in the target range of 5.6-10.0 mmol/l by 37.6 percent without increasing the risk of hypoglycemia. Thus, closed-loop insulin delivery offers a novel way to achieve effective and safe glucose control in this vulnerable patient population.