Light-Intensity Physical Activity Is Associated With Insulin Resistance in Elderly Japanese Women Independent of Moderate- to Vigorous-Intensity Physical Activity
Light-Intensity Physical Activity Is Associated With Insulin Resistance in Elderly Japanese Women Independent of Moderate- to Vigorous-Intensity Physical Activity
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DOI：
10.1123/jpah.2012-0071
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发表时间：
2014-02-01
影响因子：
3.1
通讯作者：
Miyachi, Motohiko
中科院分区：
文献类型：
--
作者：
Gando, Yuko;Murakami, Haruka;Miyachi, Motohiko
背景：目前尚不清楚轻度体力活动是否与胰岛素抵抗有益相关，类似于中度和/或剧烈体力活动。进行这项横断面研究是为了确定用三轴加速度计测定的光身体活动量与胰岛素抵抗之间的关系。方法：共有 807 名健康男性和女性参与了本研究。使用佩戴 28 天的三轴加速度计测量体力活动，并总结为光强度 (1.1-2.9 MET) 或中度至剧烈强度 (>= 3.0 MET)。通过 HOMA_R (FPG [mg/dL] x IRI [mu U/mL]/405) 评估胰岛素抵抗。结果：每日轻度体力活动时间与 HOMA_R 呈负相关（r = 0.173，P < 0.05）。调整混杂因素后，轻度体力活动和 HOMA_R 之间的关联仍然具有统计学显着性（beta = -0.119，P < .05）。进一步调整中度至剧烈强度活动后，轻度体力活动仍与 HOMA_R 显着相关（β = -0.125，P < .05）。当将轻度体力活动建模为四分位数时，也观察到类似的结果，尤其是在老年女性中。结论：这些横断面数据表明，低强度体力活动与日本老年女性的胰岛素抵抗有益相关。
Background: It is unclear whether light physical activity is beneficially associated with insulin resistance, similar to moderate and/or vigorous physical activity. This cross-sectional study was performed to determine the relationship between the amount of light physical activity, as determined with a triaxial accelerometer, and insulin resistance. Methods: A total of 807 healthy men and women participated in this study. Physical activity was measured using a triaxial accelerometer worn for 28 days and summarized as light intensity (1.1-2.9 METs) or moderate to vigorous intensity (>= 3.0 METs). Insulin resistance was evaluated by HOMA_R (FPG [mg/dL] x IRI [mu U/mL]/405). Results: The daily time spent in light physical activity was inversely associated with HOMA_R (r = 0.173, P < 0.05). After adjustment for confounders, the association between light physical activity and HOMA_R remained statistically significant (beta = -0.119, P < .05). Light physical activity remained significantly associated with HOMA_R following further adjustment for moderate to vigorous intensity activity (beta = -0.125, P < .05). Similar results were observed when light physical activity was modeled as quartiles, especially in elderly women. Conclusions: These cross-sectional data suggest that light-intensity physical activity is beneficially associated with insulin resistance in elderly Japanese women.