Airway epithelial repair: breathtakingly quick and multipotentially pathogenic
Airway epithelial repair: breathtakingly quick and multipotentially pathogenic
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DOI：
10.1136/thx.52.11.1010
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发表时间：
1997-11-01
期刊：
影响因子：
10
通讯作者：
Persson, CGA
中科院分区：
文献类型：
--
作者：
Erjefalt, JS;Persson, CGA
上皮脱落，甚至到气道剥落的程度，在19世纪后半叶已经被描述为哮喘的一个共同和统一的特征。然而，最近才在体内研究了上皮细胞脱落样损失后的修复过程。本文讨论了超快的上皮细胞恢复和上皮细胞脱落的潜在致病性后遗症。上皮细胞保护成为未来气道炎症治疗药物的一个重要特性。
Epithelial shedding, even to the point of airway denudation, had already been described as a common and unifying feature of asthma by the latter half of the 19th century. However, the repair processes that specifically follow the shedding-like loss of epithelial cells have only recently been examined in vivo. This paper discusses the exceedingly fast epithelial restitution and the potential pathogenic sequelae to epithelial shedding alone that have been unravelled. Epithelial cytoprotection emerges as an important property of future therapeutic drugs for the treatment of airways inflammatory conditions.