IL-2 ANTIBODY-PRODUCTION IN LUPUS MICE
IL-2 ANTIBODY-PRODUCTION IN LUPUS MICE
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DOI：
10.1016/0008-8749(89)90360-2
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发表时间：
1989-01-01
影响因子：
4.3
通讯作者：
TSUJII, T
中科院分区：
文献类型：
--
作者：
ISHIZAKA, S;TSUJII, T
我们在这里发现，在体内和体外，NZBWF1和BXSB小鼠中检测到对IL-2的抗体反应，而在MRL/lpr小鼠中没有。在T细胞存在或不存在的情况下，脂多糖（LPS）也能诱导NZBWF1和BXSB小鼠脾细胞产生抗il -2抗体，但在MRL/lpr脾细胞中没有。抗il -2抗体的产生随着年龄的增长而逐渐增加。NZBWF1 B细胞培养的上清液（SN）能够诱导lps刺激的正常BALB/c小鼠脾细胞产生抗il -2抗体，而NZBWF1 T细胞培养的SN则无明显影响。
We show here that antibody responses to IL-2 were detected in NZBWF1 and BXSB mice but not in MRL/lpr mice in vivo and in vitro. Lipopolysaccharide (LPS), in the presence or in the absence of T cells, also induced anti-IL-2 antibody production in NZBWF1 and BXSB mouse spleen cells but not in MRL/lpr spleen cells in vitro. Anti-IL-2 antibody production increased progressively with age. Supernatants (SN) obtained from NZBWF1 B cell cultures were able to elicit anti-IL-2 antibody production in LPS-stimulated spleen cells of normal BALB/c mice, whereas SN from NZBWF1 T cells culture had no detectable effect.