RE-EXAMINATION OF PURINE AND PYRIMIDINE SYNTHESIS IN THE 3 MAIN FORMS OF TRYPANOSOMA-CRUZI
RE-EXAMINATION OF PURINE AND PYRIMIDINE SYNTHESIS IN THE 3 MAIN FORMS OF TRYPANOSOMA-CRUZI
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DOI：
10.1016/0020-711x(79)90065-x
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发表时间：
1979-01-01
期刊：
影响因子：
--
通讯作者：
GABORAK, M
中科院分区：
文献类型：
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作者：
GUTTERIDGE, WE;GABORAK, M
本文研究了克氏锥虫血液、胞内和培养上鞭毛体中嘌呤和嘧啶的合成和回收情况。所有的形式都不能重新生物合成嘌呤环，因此依赖于回收。碱基比核苷更可取；核苷酸似乎没有被抢救出来。腺嘌呤和鸟嘌呤核苷酸很容易相互转换。尽管在体内，只有前者可能具有重要意义，但嘧啶类化合物既可以被生物合成，也可以被回收。碱基和核苷都很容易被回收；核苷酸没有得到很大程度的利用。嘧啶核糖核苷酸可以自由相互转换。在三种主要形态的寄生虫中，没有发现嘌呤和嘧啶代谢的主要差异。[AS]
Purine and pyrimidine synthesis and salvage were examined in blood trypomastigote, intracellular amastigote and culture epimastigote forms of Trypanosoma cruzi. All forms are unable to biosynthesize the purine ring de novo and are thus dependent on salvage. Bases are preferred to nucleosides; nucleotides appear not to be salvaged. Adenine and guanine nucleotides are readily interconvertible. Pyrimidines can be both biosynthesized de novo and salvaged, although in vivo, only the former is likely to be of significance. Both bases and nucleosides are readily salvaged; nucleotides are not utilized to a significant extent. Pyrimidine ribonucleotides are freely interconvertible. No major differences in purine and pyrimidine metabolism in the 3 main forms of the parasite were detected. [AS]