CXCL9 and CXCL10 bring the heat to tumors.
CXCL9 and CXCL10 bring the heat to tumors.
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DOI：
10.1126/sciimmunol.abq6509
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发表时间：
2022-07-22
影响因子：
24.8
通讯作者：
Gajewski, Thomas F
中科院分区：
文献类型：
--
作者：
Reschke, Robin;Gajewski, Thomas F
CXCL9和CXCL10可以由抗原呈递细胞（树突状细胞或巨噬细胞）和肿瘤细胞产生。Hoch等人证明，CXCL9和CXCL10与表达CCL4或CXCL13的LAG3+ T细胞共定位，并有助于产生“热”肿瘤微环境。
CXCL9 and CXCL10 can be produced by antigen-presenting cells (dendritic cells or macrophages) and by tumor cells. Hoch et al. demonstrated that CXCL9 and CXCL10 co-localize with LAG3+ T cells expressing CCL4 or CXCL13 and contribute to the generation of a "hot" tumor microenvironment.